Psychiatr Prax 2020; 47(01): 43-45
DOI: 10.1055/a-0941-3874
Kasuistik
© Georg Thieme Verlag KG Stuttgart · New York

Sexuelle Enthemmung bei Therapie mit Aripiprazol

Hypersexuality Induced by Aripiprazole
Ralf Kozian
Vinzenz von Paul Hospital, Rottweil
› Author Affiliations
Further Information

Publication History

Publication Date:
08 July 2019 (online)

Zusammenfassung

Das Auftreten einer Hypersexualität bzw. einer sexuellen Enthemmung bei Anwendung von verschiedenen Neuroleptika stellt eine Rarität dar. Bei Anwendung von Aripiprazol häufen sich jedoch Mitteilungen, nach denen es zu einer sexuellen Enthemmung bzw. auch anderen Impulskontrollstörungen wie dem pathologischen Spielen kommt. Verantwortlich dafür ist möglicherweise der Partialagonismus am D2-Rezeptor oder auch die Stimulation am 5-HT1A-Rezeptor und der 5-HT2A-Rezeptoren-Antagonismus.

Abstract

Hypersexual behavior can be assumed as a rare side effect of treatment with aripiprazole and is possibly due to partial agonism on dopamine receptors or partial agonism on 5-HT1A receptors and 5 HT2A antagonism.

 
  • Literatur

  • 1 Davidson CK, Johnson T, Jansen K. Risperidone- induced hypersexuality. Br J Psychiatry 2013; 203: 233
  • 2 Gomez EA. Hypersexuality in men receiving fluphenazine decanoate. Am J Psychiatry 1981; 138: 1263
  • 3 Moore TJ, Glenmullen J, Mattison DR. Reports of pathological gambling, hypersexuality and compulsive shopping associated with dopamine receptor agonist drugs. JAMA Intern Med 2014; 174: 1930-1933
  • 4 Etminam M, Sodhi M, Samii A. et al. Risk of gambling disorder and impulse control disorder with aripiprazole, pramipexole and ropinirole. J Clin Psychopharmacol 2017; 37: 102-104
  • 5 Gaboriau L, Victorri-Vigneau C, Gerardin M. et al. Aripiprazole: a new risk factor for pathological gambling? A report of 8 case reports. Addictive Behaviors 2014; 39: 562-565
  • 6 Gauvadan G, Magalon D, Cohen J. et al. Partial agonist therapy in schizophrenia: relevance to diminished criminal responsibility. J Forensic Sci 2010; 55: 1659-1662
  • 7 Peterson E, Forlano R. Partial dopamine agonist-induced pathological gambling and impulse-control deficit on low-dose aripiprazole. Australasian Psychiatry 2017; 25: 614-616
  • 8 Cohen J, Magalon D, Boyer L. et al. Aripiprazole-induced pathological gambling: a report of 3 cases. Current Drug Safety 2011; 6: 51-53
  • 9 Smith N, Kitchenham N, Bowden-Jones H. Pathological gambling and the treatment of psychosis with aripiprazole: case reports. Br J Psychiatry 2011; 199: 158-159
  • 10 Grall-Bronnec M, Sauvaget A, Perrouin F. et al. Pathological gambling associated with aripiprazole or dopamine replacement therapy. J Clin Psychopharmacol 2016; 36: 63-70
  • 11 Mancano MA. Gambling disorder and impulse control disorder with aripiprazole. Hosp Pharm 2017; 52: 253-257
  • 12 Reddy B, Ali M, Guruprasda S. Hypersexuality induced by aripiprazole: two cases and review of literature. Asian J Psychiatr 2017; 25: 1-3
  • 13 Cheon EJ, Bon-Hoo K, Sang SS. et al. Two cases of hypersexuality probably associated with aripiprazole. Psychiatry Investig 2013; 10: 200-202
  • 14 Das S, Chatterjee SS, Bagewadi V. Aripiprazole induced hypersexuality, when we should be cautious?. Asian J Psychiatry 2017; 29: 162-163
  • 15 Bulbena-Cabre A, Bulbena A. Aripiprazol-induced hypersexuality. Prim Care Companion CNS Disord 2016; 18: 1-2
  • 16 Schlachetzki JC, Langosch JM. Aripiprazol induced hypersexuality in a 24-year-old female patient with schizoaffective disorder?. J Clin Psychopharmacol 2008; 28: 567-568
  • 17 Benkert O, Hippius H. Hrsg. Kompendium der psychiatrischen Pharmakotherapie. Heidelberg: Springer; 2018
  • 18 Schneider LS, Dagerman K, Insel PS. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psy 2006; 14: 191-210
  • 19 Tan L, Wang HF, Wang J. et al. Efficacy and safety of atypical antipsychotic drug treatment for dementia: a systematic review and metaanalysis. Alzheimer Res Ther 2015; 7: 20
  • 20 Snoeren EMS, Veening JG, Olivier B. et al. Serotonin 1A receptors and sexual behavior in male rats: a review. Pharmacology, Biochemistry and Behavior 2014; 121: 102-114
  • 21 Oosting RS, Chan JS, Olivier B. et al. Differential effects of vilazodone versus citalopram and paroxetine on sexual behavior and serotonin transporters in male rats. Psychopharmacology 2016; 233: 1025-1034