RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000144.xml
Zeitschrift für Orthomolekulare Medizin 2019; 17(02): 5-15
DOI: 10.1055/a-0922-5198
DOI: 10.1055/a-0922-5198
Wissen
Kurzschluss im Nervensystem: Ausgewählte Umweltfaktoren und Mikronährstoffe bei Multipler Sklerose
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Juli 2019 (online)
![](https://www.thieme-connect.de/media/OM/201902/lookinside/thumbnails/10.1055a-0922-5198-1.jpg)
Zusammenfassung
Als Ursachen für die chronisch entzündliche Autoimmunerkrankung Multiple Sklerose (MS) werden neben einer genetisch bedingten Prädisposition Infektionen und weitere Faktoren wie Rauchen, Übergewicht, Fehlernährung, Stress und Vitamin-D-Mangel diskutiert. Die Ernährung hat über die Darmmikrobiota direkten Einfluss auf die Gesundheit des ZNS. Es zeichnet sich ab, dass eine Ernährung mit ω-3-Fettsäuren und viel Gemüse, Hülsenfrüchten und Vollkornprodukten durch positive Beeinflussung von Darmflora und Darmbarriere bei MS günstig wirkt. Besondere Bedeutung kommt Mikronährstoffen wie Antioxidanzien, Vitamin B12, Biotin und Vitamin A zu.
-
Literatur
- 1 Holstiege J, Steffen A, Goffrier B, Bätzing J. Epidemiologie der Multiplen Sklerose – eine populationsbasierte deutschlandweite Studie. Zentralinstitut für die kassenärztliche Versorgung in Deutschland. Versorgungsatlas-Bericht Nr. 17/09, 2017 . doi: 10.20364/VA-17.09
- 2 Goodin DS. The epidemiology of multiple sclerosis: insights to a causal cascade. Handb Clin Neurol 2016; 138: 173-206
- 3 Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med 2018; 378 (02) : 169-180
- 4 Lehmann PV, Rottlaender A, Kuerten S. The autoimmune pathogenesis of multiple sclerosis. Pharmazie 2015; 70 (01) : 5-11
- 5 Amato MP, Derfuss T, Hemmer B. et al. Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop. Mult Scler 2017; Jan 6: 1352458516686847 . doi: 10.1177/1352458516686847
- 6 Guan Y, Jakimovski D, Ramanathan M. et al. The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging. Neural Regen Res 2019; 14 (03) : 373-386
- 7 Kleinewietfeld M, Manzel A, Titze J. et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013; 496 (7446): 518-522
- 8 Handel AE, Williamson AJ, Disanto G. et al. Smoking and multiple sclerosis: An updated meta-analysis. PLoS One 2011; 6 (01) : 16149 . doi: 10.1371/journal.pone.0016149
- 9 Pierrot-Deseilligny C, Souberbielle JC. Vitamin D and multiple sclerosis: An update. Mult Scler Relat Disord 2017; 14: 35-45
- 10 Ascherio A, Munger KL, White R. et al. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol 2014; 71 (03) : 306-314
- 11 Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002; 21 (06) : 495-505
- 12 Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 2008; 233 (06) ): 674-688
- 13 La Rosa F, Clerici M, Ratto D. et al. The Gut-Brain Axis in Alzheimer’s Disease and Omega-3. A Critical Overview of Clinical Trials. Nutrients 2018; 10 (09) . pii: E1267 . doi: 10.3390/nu10091267
- 14 Menni C, Zierer J, Pallister T. et al. Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Sci Rep 2017; 7 (01) : 1079
- 15 Swank RL, Dugan BB. Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 1990; 336 (8706): 37-39
- 16 Herieka M, Erridge C. High-fat meal induced postprandial inflammation. Mol Nutr Food Res 2014; 58 (01) : 136-146
- 17 Teeman CS, Kurti SP, Cull BJ. et al. Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise. Nutr Metab (Lond) 2016; 13: 80 . eCollection 2016.
- 18 Haghikia A, Jörg S, Duscha A. et al. Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. Immunity 2015; 43 (04) : 817-829
- 19 Gold R. Multiple Sclerosis – Role of environmental Factors and Nutrition. Akt Neurol 2015; 42: 501-502
- 20 Esposito S, Bonavita S, Sparaco M. et al. The role of diet in multiple sclerosis: A review. Nutr Neurosci 2018; 21 (06) : 377-390
- 21 Bagur MJ, Murcia MA, Jiménez-Monreal AM. et al. Influence of Diet in Multiple Sclerosis: A Systematic Review. Adv Nutr 2017; 8 (03) : 463-472
- 22 Vitagione P, Mennella I, Ferracane R. et al. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Am J Clin Nutr 2015; 101 (02) : 251-261
- 23 Shinto L, Marracci G, Baldauf-Wagner S. et al. Omega-3-fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. Prostaglandins Leukot Essent Fatty Acids 2009; 80 (2-3): 131-136
- 24 Ramirez-Ramirez V, Macias-Isalas MA, Ortiz G. et al. Efficacy of fish oil on serum of TNF-α, IL-1 β, and IL-6 oxidative stress markers in multiple sclerosis treated with interferon beta-1b. Oxid Med Cell Longev 2013; 2013: 709493 . doi: 10.1155/2013/709493
- 25 Beckett JM, Bird ML, Pittaway JK, Ahuja KD. Diet and Multiple Sclerosis: Scoping Review of Web-Based Recommendations. Interact J Med Res 2019; 8 (01) : e10050
- 26 Allison DB, Bassaganya-Riera J, Burlingame B. et al. Goals in Nutrition Science 2015-2020. Front Nutr 2015; 2: 26
- 27 Fleck AK, Schuppan D, Wiendl H, Klotz L. Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis. Int J Mol Sci 2017; 18 (07) . pii: E1526. doi: 10.3390/ijms18071526
- 28 Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest 2015; 125 (03) : 926-938
- 29 David LA, Maurice CF, Carmody RN. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014; 505 (7484): 559-563
- 30 Smits SA, Leach J, Sonnenburg ED. et al. Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania. Science 2017; 357 (6353): 802-806
- 31 Calvo-Barreiro L, Eixarch H, Montalban X, Espejo C. Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis. Autoimmun Rev 2018; 17 (02) : 165-174
- 32 Bravo JA, Forsythe P, Chew MV. et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A 2011; 108 (38) : 16050-16055
- 33 Tilg H, Moschen AR, Kaser A. Obesity and the microbiota. Gastroenterology 2009; 136 (05) : 1476-1483
- 34 Wu GD, Chen J, Hoffmann C. et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011; 334 (6052): 105-108
- 35 Cosorich I, Dalla-Costa G, Sorini C. et al. High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis. Sci Adv 2017; 3 (07) : e1700492 . doi: 10.1126/sciadv.1700492
- 36 Erny D, Hrabě de Angelis AL, Jaitin D. et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 2015; 18 (07) : 965-977
- 37 Weinstein LI, Revuelta A, Pando RH. Catecholamines and acetylcholine are key regulators of the interaction between microbes and the immune system. Ann N Y Acad Sci 2015; 1351: 39-51
- 38 Berer K, Gerdes LA, Cekanaviciute E. et al. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 2017; 114 (40) : 10719-10724
- 39 Christ A, Günther P, Lauterbach MAR. et al. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell 2018; 172 (1-2): 162-175
- 40 Tasset I, Agüera E, Sánchez-López F. et al. Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clin Biochem 2012; 45 (06) : 440-444
- 41 Wang P, Xie K, Wang C, Bi J. Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosis. Eur Neurol 2014; 72 (3–4): 249-254
- 42 Socha K, Kochanowicz J, Karpioska E. et al. Dietary habits and selenium, glutathione peroxidase and total antioxidant status in the serum of patients with relapsing-remitting multiple sclerosis. Nutr J 2014; 13: 62 . doi: 10.1186/1475-2891-13-62
- 43 Siotto M, Filippi MM, Simonelli I. et al. Oxidative Stress Related to Iron Metabolism in Relapsing Remitting Multiple Sclerosis Patients With Low Disability. Front Neurosci 2019; 13: 86
- 44 Moccia M, Capacchione A, Lanzillo R. et al. Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis. Ther Adv Neurol Disord 2019; 12: 1756286418819074 . doi: 10.1177/1756286418819074
- 45 Solovyev ND. Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling. J Inorg Biochem 2015; 153: 1-12
- 46 Zhai J, Bo Y, Lu Y. et al. Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. PLoS One 2017; 12 (01) : e0170172 . doi: 10.1371/journal.pone.0170172
- 47 Sanoobar M, Eghtesadi S, Azimi A. et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutr Neurosci 2015; 18 (04) : 169-176
- 48 Gröber U, Kisters K, Schmidt J. Neuroenhancement with Vitamin B12: Underestimated neurological significance. Nutrients 2013; 5 (12) : 5031-5045
- 49 Dardiotis E, Arseniou S, Sokratous M. et al. Vitamin B12, folate, and homocysteine levels and multiple sclerosis: A Meta-analysis. Mult Scler Relat Disord 2017; 17: 190-197
- 50 Fahmy EM, Elfayoumy NM, Abdelalim AM. et al. Relation of serum levels of homocysteine, vitamin B12 and folate to cognitive functions in multiple sclerosis patients. Int J Neurosci 2018 . doi: 10.1080/00207454.2018.1435538
- 51 Gröber U. Mikronährstoffe. Metabolic Tuning – Prävention – Therapie. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2011
- 52 Alfadhel M, Tabarki B. SLC19A3 Gene Defects Sorting the Phenotype and Acronyms: Review. Neuropediatrics 2018; 49 (02) : 83-92
- 53 Sedel F, Challe G, Vignal C. et al. A novel biotin sensitive leukodystrophy. J Inherit Metab Dis 2011; 34: S267
- 54 Sedel F, Papeix C, Bellanger A. et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Mult Scler Relat Disord 2015; 4 (02) : 159-169
- 55 Tourbah A, Lebrun-Frenay C, Edan G. et al. MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study. Mult Scler 2016; 22 (13) : 1719-1731
- 56 Mock DM. Biotin: From Nutrition to Therapeutics. J Nutr 2017; 147 (08) : 1487-1492
- 57 Spain R, Powers K, Murchison C. et al. Lipoic acid in secondary progressive MS: A randomized controlled pilot trial. Neurol Neuroimmunol Neuroinflamm 2017; 4 (05) : e374
- 58 Bittner F, Murchison C, Koop D. et al. Lipoic Acid Pharmacokinetics at Baseline and 1 year in Secondary Progressive MS. Neurol Neuroimmunol Neuroinflamm 2017; 4 (05) : e380
- 59 Bitarafan S, Saboor-Yaraghi A, Sahraian MA. et al. Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial. Iran J Allergy Asthma Immunol 2016; 15 (01) : 13-19
- 60 Fragoso YD, Stoney PN, McCaffery PJ. The evidence for a beneficial role of vitamin A in multiple sclerosis. CNS Drugs 2014; 28 (04) : 291-299