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Exp Clin Endocrinol Diabetes 2021; 129(06): 407-412
DOI: 10.1055/a-0895-5275
Article

Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Dongxue Zhang
1   Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
,
Wenyan Liu
1   Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
,
Ran Miao
2   Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
,
Lei Wang
3   Department of Stomatology, Chuiyangliu Hospital, Tsinghua University, Beijing, China
,
Xuan Zhou
1   Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
,
Haiyan Wang
1   Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
,
Yufeng Li
4   Department of Endocrinology, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China
,
Zuomin Wang
1   Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Abstract

Background This study explores the association between chronic periodontitis and renal dysfunction in type 2 diabetic mellitus (T2DM) patients.

Methods An observational study was conducted in 169 T2DM patients with chronic periodontitis. Patients were divided into 2 groups according to presence of normal renal function (n=111) and renal dysfunction (n=58), and oral health behavior-related variables were obtained by questionnaire. Periodontal status was examined, and pocket probing depth (PD), clinical attachment level (CAL), and bleeding index (BI) were measured.

Results The severe periodontitis group had a significant higher HbA1c level (8.53 ± 1.61%) as compared with the mild and moderate periodontitis groups (7.68±1.58%) and (7.35±1.45%), P=0.001. Compared with patients with normal renal function, patients with renal dysfunction had a higher PD value, higher CAL value, fewer remaining teeth, and were less likely to have remaining teeth ≥20. The percentage of sites with PD ≥4 mm (52.8% vs. 41.67%) was significantly greater in patients with renal dysfunction. There was no difference in the scores of oral health knowledge assessment between the 2 groups. After adjustment by gender, age, BMI, smoking, hypertension, and HbA1c, the percentage of the sites with PD≥4 mm was an independent risk factor of renal dysfunction in T2DM patients.

Conclusion In patients with T2DM, those with periodontitis may be more susceptible to decreased kidney function.

Key words

periodontal disease - diabetic nephropathy - type 2 diabetes mellitus - periodontitis - risk factors


Publication History

Received: 17 December 2018
Received: 10 March 2019

Accepted: 15 April 2019

Article published online:
02 May 2019

© 2019. Thieme. All rights reserved.

© Georg Thieme Verlag KG
Stuttgart · New York

 

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