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Diabetes aktuell 2019; 17(03): 110-112
DOI: 10.1055/a-0890-5603
DOI: 10.1055/a-0890-5603
Schwerpunkt
Infektionen in der Schwangerschaft und frühen Kindheit
Risiko für Betazell-Autoimmunität und Typ-1-Diabetes?Further Information
Publication History
Publication Date:
17 May 2019 (online)
![](https://www.thieme-connect.de/media/diabetakt/201903/lookinside/thumbnails/10-1055-a-0890-5603-1.jpg)
Zusammenfassung
Die Autoimmunerkrankung Typ-1-Diabetes ist durch einen Verlust der insulinproduzierenden Betazellen im Pankreas charakterisiert. Infektionen könnten potentielle Umweltfaktoren darstellen, die in genetisch prädisponierten Personen einen Autoimmunprozess gegen die Betazellen auslösen und/oder dessen Progression zum klinisch-manifesten Typ-1-Diabetes beschleunigen. Insbesondere für enterovirale Infektionen wurden Assoziationen mit der Entwicklung von Betazell-Autoimmunität und Typ-1-Diabetes nachgewiesen. Effektive Impfstrategien gegen Enteroviren könnten deshalb in Zukunft zur Prävention des Typ-1-Diabetes dienen.
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