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Horm Metab Res 2019; 51(04): 261-266
DOI: 10.1055/a-0867-0886
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome

Meryem Kuru Pekcan
1   Department of Obstetrics and Gynecology, University of Health Sciences, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey
,
Aytekin Tokmak
1   Department of Obstetrics and Gynecology, University of Health Sciences, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey
,
Hatice Akkaya
1   Department of Obstetrics and Gynecology, University of Health Sciences, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey
,
Gültekin Pekcan
2   Department of Internal Medicine, Ankara University Medical Faculty, Ankara, Turkey
,
Andaç Onur
3   Department of Medical Biochemistry, Numune Training and Research Hospital, Ankara, Turkey
,
Üçler Kısa
4   Department of Medical Biochemistry, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
,
Aylin Pelin Çil
5   VKV American Hospital, Women's Healthcare Centre, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

received 23 May 2018

accepted 26 February 2019

Publication Date:
25 April 2019 (online)

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Abstract

The purpose of this study was to assess the rate of insulin resistance (IR) and the relationship between IR and high-molecular weight adiponectin (HMWA) in patients with polycystic ovary syndrome (PCOS). A cross sectional study involving 43 women with PCOS and 39 normal women was carried out over a period of nine months. Fasting glucose and insulin levels, lipid parameters and androgen levels were measured in all serum samples. HMWA was determined by enzyme-linked immunosorbent assay and IR was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index. The IR was more prevalent in the PCOS group than in the controls (p=0.002). Dehydroepiandrosterone sulfate, sex hormone binding globulin, free androgen index, total testosterone, insulin, and HOMA-IR levels were significantly higher in the PCOS group as compared to the control group (all p<0.05). Moreover, HMWA was significantly lower and negatively correlated with the clinical and biochemical hyperandrogenism in the PCOS group. HMWA and HOMA-IR were also associated with triglyceride, body mass index, and fat mass in this group. ROC curve analyses demonstrated that the AUC, indicative of the HMWA value for discriminating PCOS with IR, was 0.725, with a confidence interval of 0.615–0.835 (p=0.001). The serum HMWA levels are lower in patients with PCOS, which suggest that HMWA might be involved in the pathogenesis of PCOS. We also conclude that HMWA might be a strong determinant of IR in PCOS patients.

Key words

polycystic ovarian syndrome - high-molecular weight adiponectin - insulin resistance - hyperandrogenemia - HOMA-IR
 

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