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DOI: 10.1055/a-0834-4134
Ästhetische Behandlungen mit Fillern und das Management von Nebenwirkungen
Aesthetic Filler Injections and the Management of Side EffectsPublication History
Publication Date:
09 April 2019 (online)
Zusammenfassung
Medizinisch-ästhetische Behandlungen sind für die tägliche dermatologische Praxis von zunehmender Bedeutung. Als zentraler Bestandteil eines multimodalen Therapiekonzeptes sind dermale und Volumenfiller aus der modernen ästhetischen Therapie nicht mehr wegzudenken. Wegweisende Erkenntnisse zum Alterungsprozess des Gesichtes und zur Sicherheit und Spezifika der verschiedenen Typen von Füllstoffen der vergangenen Jahre bieten heute differenzierte Anwendungsmöglichkeiten von Volumenaugmentation bis hin zu Hydratation oder Kollageninduktion. Gleichsam sind aber auch der Markt an verfügbaren Injektionsprodukten und die verschiedenen Indikationen und Injektionstechniken nahezu unüberschaubar. Schließlich werden wir in der Praxis immer wieder mit Komplikationen nach unsachgemäßer Anwendung oder den Langzeitkomplikationen von in Deutschland längst nicht mehr verfügbaren Füllstoffen konfrontiert und auch bei regelhafter Injektion sind Nebenwirkungen nicht ausgeschlossen. Die vorliegende Arbeit soll einen Überblick über die am Markt verfügbaren aber auch relevanten historischen bzw. obsoleten Filler und ferner über mögliche Komplikationen und deren Management geben. Ferner finden sich persönliche Bewertungen zu besonderen Indikationen bzw. Injektionstechniken.
Abstract
Over the past years aesthetic procedures have been evolving as an important part of daily dermatological practice. Herein, fillers represent an integral component of a modern, multimodal aesthetic treatment approach. Advances in the understanding of the aging face and modern fillers offer a broad variety of indications ranging from augmentation to hydration or collagen-induction. At the same time the range of available injection materials, products and techniques has grown to mere unmanageable dimensions. Finally, dermatologists are frequently confronted with the consequences of improper filler treatments or late side effects of early filler materials which have already disappeared from the market and even the experienced injector may encounter treatment-associated side effects. Here, we review the most important current and historic filler materials, including indications, injection techniques, adverse effects and the respective management recommendations.
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Literatur
- 1 Carruthers J, Carruthers A, Humphrey S. Introduction to Fillers. Plast Reconstr Surg 2015; 136 (Suppl. 05) 120S-131S
- 2 Hartmann D, Heppt M, Gauglitz GG. Management and prevention of adverse events in esthetic interventions. Hautarzt 2015; 66: 764-771
- 3 Rzany B, DeLorenzi C. Understanding, Avoiding, and Managing Severe Filler Complications. Plast Reconstr Surg 2015; 136 (Suppl. 05) 196S-203S
- 4 Carle MV, Roe R, Novack R. et al. Cosmetic facial fillers and severe vision loss. JAMA Ophthalmol 2014; 132: 637-639
- 5 Heppt M, Hartmann D, Reinholz M. et al. Fillers and associated side effects. HNO 2015; 63: 472-480
- 6 Hartmann D, Ruzicka T, Gauglitz GG. Complications associated with cutaneous aesthetic procedures. J Dtsch Dermatol Ges 2015; 13: 778-786
- 7 Alcalay J, Alkalay R, Gat A. et al. Late-onset granulomatous reaction to Artecoll. Dermatol Surg 2003; 29: 859-862
- 8 Alijotas-Reig J, Garcia-Gimenez V, Miro-Mur F. et al. Delayed immunemediated adverse effects related to polyacrylamide dermal fillers: clinical findings, management, and follow-up. Dermatol Surg 2009; 35 (Suppl. 01) 360-366
- 9 Altmeyer MD, Anderson LL, Wang AR. Silicone migration and granuloma formation. J Cosmet Dermatol 2009; 8: 92-97
- 10 Yutskovskaya Y, Kogan E, Leshunov E. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs Dermatol 2014; 13: 1047-1052
- 11 Yutskovskaya YA, Kogan EA. Improved Neocollagenesis and Skin Mechanical Properties After Injection of Diluted Calcium Hydroxylapatite in the Neck and Decolletage: A Pilot Study. J Drugs Dermatol 2017; 16: 68-74
- 12 Reszko AE, Sadick NS, Magro CM. et al. Late-onset subcutaneous nodules after poly-L-lactic acid injection. Dermatol Surg 2009; 35 (Suppl. 01) 380-384
- 13 Klein AW, Rish DC. Dermatology: bovine injectable collagen. West J Med 1985; 143: 231
- 14 Watson W, Kaye RL, Klein A. et al. Injectable collagen: a clinical overview. Cutis 1983; 31: 543-546
- 15 Juhlin L. Hyaluronan in skin. J Intern Med 1997; 242: 61-66
- 16 Bissell MJ, Hall HG, Parry G. How does the extracellular matrix direct gene expression?. J Theor Biol 1982; 99: 31-68
- 17 Laurent TC, Fraser JR. Hyaluronan. FASEB J 1992; 6: 2397-2404
- 18 Tammi R, Ripellino JA, Margolis RU. et al. Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe. J Invest Dermatol 1988; 90: 412-414
- 19 Scott JE. Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues. FASEB J 1992; 6: 2639-2645
- 20 Turlier V, Delalleau A, Casas C. et al. Association between collagen production and mechanical stretching in dermal extracellular matrix: in vivo effect of cross-linked hyaluronic acid filler. A randomised, placebo-controlled study. J Dermatol Sci 2013; 69: 187-194
- 21 Rock K, Fischer K, Fischer JW. Hyaluronan used for intradermal injections is incorporated into the pericellular matrix and promotes proliferation in human skin fibroblasts in vitro. Dermatology 2010; 221: 219-228
- 22 Kaya G, Tran C, Sorg O. et al. Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. PLoS Med 2006; 3: e493
- 23 Streker M, Reuther T, Krueger N. et al. Stabilized hyaluronic acid-based gel of non-animal origin for skin rejuvenation: face, hand, and decolletage. J Drugs Dermatol 2013; 12: 990-994
- 24 Hilton S, Schrumpf H, Buhren BA. et al. Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients. Eur J Med Res 2014; 19: 30
- 25 Buhren BA, Schrumpf H, Hoff NP. et al. Hyaluronidase: from clinical applications to molecular and cellular mechanisms. Eur J Med Res 2016; 21: 5
- 26 Wohlrab J, Finke R, Franke WG. et al. Efficacy study of hyaluronidase as a diffusion promoter for lidocaine in infiltration analgesia of skin. Plast Reconstr Surg 2012; 129: 771e-772e
- 27 Hirsch RJ, Brody HJ, Carruthers JD. Hyaluronidase in the office: a necessity for every dermasurgeon that injects hyaluronic acid. Journal of Cosmetic and Laser Therapy 2007; 9: 182-185
- 28 Wohlrab J, Wohlrab D, Wohlrab L. et al. Use of hyaluronidase for pharmacokinetic increase in bioavailability of intracutaneously applied substances. Skin Pharmacol Physiol 2014; 27: 276-282
- 29 Jahn K, Homey B, Gerber PA. Management of complications after aesthetic hyaluronic acid injections. Hautarzt 2014; 65: 851-853
- 30 Kim DW, Yoon ES, Ji YH. et al. Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management. JPRAS 2011; 64: 1590-1595
- 31 Juhasz MLW, Levin MK, Marmur ES. The Kinetics of Reversible Hyaluronic Acid Filler Injection Treated With Hyaluronidase. Dermatol Surg 2017; 43: 841-847
- 32 Funt DK. Avoiding malar edema during midface/cheek augmentation with dermal fillers. J Clin Aesthet Dermatol 2011; 4: 32-36