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Drug Res (Stuttg) 2019; 69(08): 445-450
DOI: 10.1055/a-0809-5098
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis and Anticonvulsant Studies of Thiazolidinone and Azetidinone Derivatives from Indole Moiety

Archana,
Sachin Saini
2   Research Scholar, Department of Chemistry, Mewar University, Rajasthan, India
› Author Affiliations
Further Information

Publication History

received 08 October 2018

accepted 27 November 2018

Publication Date:
20 December 2018 (online)

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Abstract

2-Amino-5-(3’-indolomethylene)-1, 3 , 4 - oxadiazole (3) undergoes facile condensation with various aromatic aldehydes to gave 2-substitiuted arylidenylamino-5-(3’- indolomethylene) – 1, 3 , 4 – oxadiazole (4–8). Cyclocondensation of (4–8) with thioglycolic acid and triethylamine yielded 3-[5’-(3”- indolomethylene)- 1’, 3’, 4’- oxadiazol-2’-yl]- 2- (substituted aryl)-4- thiazolidinones (9–13) and 1-[5’-(3”- indolomethylene) -1’, 3’, 4’- oxadiazol - 2’- yl ] -4-(substituted aryl) -2- azetidinones (14–18). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesised compounds were evaluated for their anticonvulsant activity and acute toxicity.

Key words

Indolyl oxadiazole - indolyl thazolidinones - indolyl azetidinones - spectral studies - anticonvulsant activity - acute toxicity
 

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