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Drug Res (Stuttg) 2019; 69(07): 365-373
DOI: 10.1055/a-0806-7207
Review
© Georg Thieme Verlag KG Stuttgart · New York

Mechanistic Pathways of ATP Sensitive Potassium Channels Referring to Cardio-Protective Effects and Cellular Functions

Vishal Kumar Vishwakarma
1   Department of Pharmacology, R.R.S College of Pharmacy, Amethi, Uttar Pradesh, India
,
Prabhat Kumar Upadhyay
2   Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
,
Hridaya Shanker Chaurasiya
1   Department of Pharmacology, R.R.S College of Pharmacy, Amethi, Uttar Pradesh, India
,
Ritesh Kumar Srivasatav
3   Faculty of Pharmacy, Kamla Nehru Institute of Management and Technology, Sultanpur, India
,
Tarique Mahmood Ansari
4   Department of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Vivek Srivastava
1   Department of Pharmacology, R.R.S College of Pharmacy, Amethi, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

received 04 October 2018

accepted 23 November 2018

Publication Date:
04 January 2019 (online)

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Abstract

A study of potassium channels correlates the fundamentals of mechanistic pathways and various physiological functions. The knowledge of these pathways provides the background, how to determine unit cell functions and to affect cardio protection. ATP sensitive potassium channels adjust excitability of membrane and functions as per metabolic status of cell. A lot of energy consumption primarily occurred in skeletal muscles which also express high number of potassium channels. The increase in calcium release and high heat production is occurred due to loss of potassium channels. Such type of mediations determines metabolic changes and energy required in the dissipation. IPC reduces infarct size in anesthetized mice. In ischemic-reperfusion, pressure in left ventricle was watched while contractile power recovery did not happen. It was seen that elements of intact potassium channel are fundamental for Ischemic preconditioning (IPC). If more prominent is enactment of potassium channels and their cardiologic effects create high heart rate. All the more as of late, it has been suggested that mitochondrial ATP sensitive potassium channels are critical as closing stage effectors which trigger IPC as opposed to sarcolemmal potassium channels. Nevertheless, the importance of the potassium channels reconsidered in cardio-protection in present findings. These discoveries recommend that potassium channels in the adjusting ischemic-reperfusion damage in mice. The heart rate of the mouse occurred during ischemia; enhance watchful extrapolation applied to larger warm blooded animals.

Key words

potassium channel - ischemic preconditioning - cardio-protection - skeletal muscle
 

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