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DOI: 10.1055/a-0799-7042
In-vitro-Untersuchungen zur Weidenmistel an verschiedenen humanen Tumorzelllinien
Investigations of Willow Mistletoe on Various Human Tumor Cell Lines in vitroPublication History
Eingereicht 07 January 2019
Revision akzeptiert 20 May 2019
Publication Date:
10 July 2019 (online)
![](https://www.thieme-connect.de/media/phyto/201903/lookinside/thumbnails/10.1055a-0799-7042-1.jpg)
Zusammenfassung
Traditionell werden pharmazeutische Zubereitungen der Weidenmistel häufig bei der Therapie von Blasen- und Nierenzellkarzinomen eingesetzt. Dennoch existieren bislang nur wenige wissenschaftliche Untersuchungen zu Wirkmechanismen von Weidenmistelpräparaten. Daher wurde mithilfe verschiedener Testverfahren die Hemmung der Viabilität von Tumorzellen durch den Weidenmistelextrakt Iscucin® Salicis bestimmt und die beteiligten Mechanismen untersucht. Des Weiteren wurde die Hemmung der Zellmigration analysiert.
Ergebnisse Der Extrakt hemmte Zellwachstum und -migration in vitro, wobei die Sensitivität der einzelnen Tumorzelllinien variierte. Vor allem sprachen neuroepitheliale Tumorzellen und Bronchialkarzinomzellen gut an. Zudem wurden pro-apoptotische Marker aktiviert. Klinische Untersuchungen stehen aus, um zu klären, bei welchen Tumoren das größte Potenzial für eine Behandlung mit Iscucin® Salicis besteht.
Abstract
Traditionally, pharmaceutically produced mistletoe preparations from willow tree are often used for treating bladder and renal cell carcinomas. However, only little data from preparations from willow mistletoe have been published so far and the underlying mechanisms are not completely known. The inhibitory effects of an extract from mistletoe from willow tree (Iscucin® Salicis) on the viability of cancer cells and feasible mechanisms were investigated using different assays. Furthermore, the inhibition of cell migration was analysed.
Results The extract inhibited cell growth and migration in vitro, with varying intensity depending on the respective cell line. Especially neuro-epithelial tumor cells and bronchial carcinoma cells showed a good response. Moreover, pro-apoptotic markers were activated. Clinical investigations should clarify, which types of cancer have the highest potential for a treatment with Iscucin® Salicis.
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