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Exp Clin Endocrinol Diabetes 2019; 127(02/03): 81-83
DOI: 10.1055/a-0752-4176
DOI: 10.1055/a-0752-4176
Editorial
The Adrenal Gland: Central Relay in Health and Disease
Weitere Informationen
Publikationsverlauf
received 25. September 2018
revised 25. September 2018
accepted 28. September 2018
Publikationsdatum:
27. Februar 2019 (online)
![](https://www.thieme-connect.de/media/eced/20190203/lookinside/thumbnails/09-2018-0407-endo_10-1055-a-0752-4176-1.jpg)
Diseases of the adrenal gland are as important for the general practitioner as for the endocrine specialist. The high prevalence of some adrenal endocrinopathies, such as adrenal incidentalomas (1–2% of the population) and primary aldosteronism (6% of hypertensives), which affect millions of patients, makes adrenal diseases a relevant health issue. The high morbidity and mortality of some of the rarer adrenal diseases, i. e., Addison’s disease and Cushing’s syndrome ([Table 1]), make early detection and appropriate treatment such a challenge for the health care system.
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References
- 1 Prada ETA, Burrello J, Reincke M. et al. Old and New Concepts in the Molecular Pathogenesis of Primary Aldosteronism. Hypertension. 2017; 70: 875-881. doi:10.1161/HYPERTENSIONAHA.117.10111.
- 2 Albani A, Theodoropoulou M, Reincke M. Genetics of Cushing's disease. Clin Endocrinol (Oxf) 2018; 88: 3-12. doi:10.1111/cen.13457.
- 3 Fassnacht M, Arlt W, Bancos I. et al. Management of adrenal incidentalomas: European society of endocrinology clinical practice guideline in collaboration with the European network for the study of adrenal tumors. Eur J Endocrinol 2016; 175: G1-G34. doi:10.1530/EJE-16-0467.
- 4 Crona J, Taïeb D, Pacak K. New Perspectives on Pheochromocytoma and Paraganglioma: Toward a molecular classification. Endocr Rev 2017; 38: 489-515 doi:10.1210/er.2017-00062.
- 5 Schilbach K, Junnila R, Bidlingmaier M.. The aldosterone to renin ratio as screening tool in primary aldosteronism. Exp Clin Endocrinol Diabetes 2019; 127: 84-92
- 7 Pérez-Rivas LG, Williams T, Reincke M.. Inherited forms of primary hyperaldosteronism: new genes, new phenotypes and proposition of a new classification. Exp Clin Endocrinol Diabetes 2018; 12: 93-99
- 6 Mulatero P, Tizzani D, Viola A. et al. Prevalence and characteristics of familial hyperaldosteronism: The PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms). Hypertension 2011; 58: 797-803 doi:10.1161/HYPERTENSIONAHA.111.175083.
- 8 Yang Y, Reincke M, Williams T.. Treatment of unilateral PA by adrenalectomy: Potential reasons for incomplete biochemical cure. Exp Clin Endocrinol Diabetes 2019; 127: 100-108
- 9 Williams TA, Lenders JWM, Mulatero P. et al. Outcomes after adrenalectomy for unilateral primary aldosteronism: An international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol 2017; 5: 689-699 doi:10.1016/S2213-8587(17)30135-3.
- 10 Fassnacht M, Terzolo M, Allolio B. et al. Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med 2012; 366: 2189-2197. doi:10.1056/NEJMoa1200966.
- 11 Kroiss M, Deutschbein T, Schlötelburg W. et al. Treatment of Refractory Adrenocortical Carcinoma with Thalidomide: Analysis of 27 Patients from the European Network for the Study of Adrenal Tumours Registry.. Exp Clin Endocrinol Diabetes 2018; DOI: 10.1055/a-0747-5571.
- 12 Megerle F, Kroiss M, Hahner S, Fassnacht M. Advanced Adrenocortical Carcinoma - What to do when First-Line Therapy Fails?. Exp Clin Endocrinol Diabetes 2019; 127: 109-116
- 13 Nölting S, Grossman AB, Pacak K.. Metastatic Phaeochromocytoma: Spinning towards more promising treatment options. Exp Clin Endocrinol Diabetes 2019; 127: 117-128
- 14 Erlic Z, Beuschlein F. Metabolic alterations in patients with pheochromocytoma. Exp Clin Endocrinol Diabetes 2019; 127: 129-136
- 15 Schreiner F, Anand G, Beuschlein F.. Perioperative management of endocrine active adrenal tumors. Exp Clin Endocrinol Diabetes 2019; 127: 137-146
- 16 Petersenn S, Beckers A, Ferone D. et al. Therapy of endocrine disease: outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: Systematic review assessing criteria used to define remission and recurrence. Eur J Endocrinol. 2015; 172: R227-R239. doi:10.1530/EJE-14-0883.
- 17 Stalla GK, Ciato D, Dimopoulou C. Cushing's disease. Exp Clin Endocrinol Diabetes 2019; 127: 147-155
- 18 Kamilaris CDC, Faucz FR, Voutetakis A. Stratakis CA. et al. Carney complex. Exp Clin Endocrinol Diabetes 2019; 127: 156-164
- 19 Barthel A, Benker G, Berens K. et al. An update on Addison's disease. Exp Clin Endocrinol Diabetes 2019; 127: 165-170
- 20 Reisch N. Review of health problems in adult patients with congenital adrenal hyperplasia. Exp Clin Endocrinol Diabetes 2019; 127: 171-177
- 21 Di Dalmazi G.. Adrenal incidentaloma: picking out the high-risk patients. Exp Clin Endocrinol Diabetes 2019; 127: 178-184
- 22 http://www.dfg.de/gefoerderte_projekte/programme_und_projekte/listen/projektdetails/index.jsp?id=314061271