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Z Geburtshilfe Neonatol 2019; 223(01): 48-53
DOI: 10.1055/a-0660-9734
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Levels of Glucagon-like Peptide 1 are Decreased in Macrosomic Neonates from Non-Diabetic Mothers

Ayla Aktulay
1   Obstetrics and gynecology, University of Health Sciences, Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey
,
Yaprak Engin-Ustun
1   Obstetrics and gynecology, University of Health Sciences, Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey
,
Ozlem Gunduz Yasar
1   Obstetrics and gynecology, University of Health Sciences, Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey
,
Canan Yilmaz
2   Biochemistry, Gazi University, School of Medicine, Ankara, Turkey
,
Salim Erkaya
1   Obstetrics and gynecology, University of Health Sciences, Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey
,
A. Seval Ozgu-Erdinc
3   Perinatology, University of Health Sciences, Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

received 03 April 2018

accepted 17 July 2018

Publication Date:
24 August 2018 (online)

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Abstract

Glucagon-like peptide 1 (GLP-1) is a gut-derived peptide with insulin-like effects. Our aim was to analyze cord blood GLP-1 levels of macrosomic and appropriate-gestational-age (AGA) neonates from non-diabetic mothers. A case-control study was conducted with 22 term macrosomic neonates (birth weight≥4000 g) and 22 AGA (birth weight>10th percentile and<4000 g) pregnancies. Cord blood GLP-1 levels of neonates were measured. There were no significant differences in maternal age, gestational age and gravida between the 2 groups. Umbilical cord blood GLP-1 levels were significantly lower in macrosomic neonates (6.9±2.9 pg/mL) compared with control group (10.3±3.7 pg/mL) (p=0.002). Binary logistic regression analysis showed only the maternal BMI to be an independent statistically significant predictor of macrosomia (odds ratio=2.459; 95% CI, 1.170–5.170; P=0.018). The results of our study revealed decreased GLP-1 levels in macrosomic neonates, and maternal BMI was an independent predictor of macrosomia.

Key words

Glucagon-like peptide 1 - macrosomia

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