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Planta Med 2018; 84(17): 1232-1248
DOI: 10.1055/a-0656-7262
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Traditional Uses, Phytochemistry, and Antimicrobial Activities of Eugenia Species – A Review

Angela Maria de Souza
Postgraduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, Parana, Brazil
,
Camila Freitas de Oliveira
Postgraduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, Parana, Brazil
,
Vinícius Bednarczuk de Oliveira
Postgraduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, Parana, Brazil
,
Fernando Cesar Martins Betim
Postgraduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, Parana, Brazil
,
Obdulio Gomes Miguel
Postgraduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, Parana, Brazil
,
Marilis Dallarmi Miguel
Postgraduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, Parana, Brazil
› Author Affiliations
Further Information

Publication History

received 16 April 2018
revised 26 June 2018

accepted 05 July 2018

Publication Date:
17 July 2018 (online)

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Abstract

Antimicrobial resistance is a critical health problem, and pathogens responsible for common infections have developed resistance to antimicrobials, posing a threat to global health and placing a huge burden on health services. During the past two decades, the search for new bioactive agents in nature has become extremely important for promoting health and in the development of more efficient antimicrobials. The genus Eugenia is one of the largest in the Myrtaceae family, comprising approximately 1000 species from Mexico to Argentina, with a few species distributed in Australia and Africa. Eugenia species are used in folk medicine, with antidiabetic, antirheumatic, antipyretic, anti-inflammatory, antidiarrheal, antifungal, and antibacterial properties. This study systematically reviews the Eugenia species to compile the phytochemical composition and antimicrobial effects. In addition, we provide information regarding the traditional uses and cytotoxic activity of Eugenia species. We conducted a systematic literature search of specialized databases (Web of Science, Scielo, Lilacs, Pubmed, Science Direct, Scopus) and selected articles published between 1973 and 2015 using Eugenia and antimicrobial activity, Eugenia and toxicity, and Eugenia and chemical composition as key words. Ninety-three studies were included, and the phytochemical analyses from these studies show that Eugenia species are a rich source of flavonoids, tannins, triterpenes, and sesquiterpenes. Chemical constituents play an apparent role in the antimicrobial effects and reinforce the known antimicrobial potential of the Eugenia genus. It is worth mentioning that some Eugenia species cause significant cytotoxicity.

Key words

Eugenia species - Myrtaceae family - chemical composition - antimicrobial activity - toxicity
 

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