Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata

Ran Wen; Haining Lv; Yong Jiang; Pengfei Tu

doi:10.1055/a-0626-7356

Planta Medica, Table of Contents

Planta Med 2018; 84(16): 1174-1182
DOI: 10.1055/a-0626-7356

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata

Ran Wen

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, Peopleʼs Republic of China

,

Haining Lv

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, Peopleʼs Republic of China

,

Yong Jiang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, Peopleʼs Republic of China

,

Pengfei Tu

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, Peopleʼs Republic of China

› Author Affiliations

Abstract

A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the specific rotations and electronic circular dichroism spectra, application of Mosherʼs method, and by comparing the calculated and experimental electronic circular dichroism spectra. The isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells. All of the isolated compounds exhibited inhibitory effects against nitric oxide production, and most of them showed obvious anti-inflammatory activities (IC₅₀ < 20 µM), among which 26 was the most active compound with an IC₅₀ of 9.6 µM.

Key words

Pongamia pinnata - Leguminosae - flavanones - flavanols - anti-inflammatory effect - nitric oxide inhibition

Full Text

References

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