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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2019; 54(05): 524-530
DOI: 10.1016/j.rbo.2018.02.002
Artigo Original | Original Article
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revnter Publicações Ltda Rio de Janeiro, Brazil

The Impact of Lung Carcinoma Histology on the Frequency of Bone Metastases[*]

Article in several languages: português | English
Marcelo Bragança dos Reis Oliveira 
1   Serviço de Traumato-Ortopedia, Universidade Federal do Rio de Janeiro (UFRJ), Hospital Universitário Clementino Fraga Filho, (HUCFF), Rio de Janeiro, RJ, Brasil
,
Larissa Costa Souza
1   Serviço de Traumato-Ortopedia, Universidade Federal do Rio de Janeiro (UFRJ), Hospital Universitário Clementino Fraga Filho, (HUCFF), Rio de Janeiro, RJ, Brasil
,
Ermides Javier Garcia Sampayo
1   Serviço de Traumato-Ortopedia, Universidade Federal do Rio de Janeiro (UFRJ), Hospital Universitário Clementino Fraga Filho, (HUCFF), Rio de Janeiro, RJ, Brasil
,
Gustavo Sobral de Carvalho
1   Serviço de Traumato-Ortopedia, Universidade Federal do Rio de Janeiro (UFRJ), Hospital Universitário Clementino Fraga Filho, (HUCFF), Rio de Janeiro, RJ, Brasil
,
Fernanda Carvalho de Queiroz Mello
2   Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil
,
Marcos Eduardo Machado Paschoal
3   Instituto de Doenças do Tórax,Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil
› Author Affiliations
Further Information

Publication History

12 September 2017

21 February 2018

Publication Date:
19 September 2019 (online)

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Abstract

Objective Lung cancer is the leading cause of death by cancer, and the bones are one of the most common sites of metastasis from this condition. This study aimed to evaluate the influence of lung carcinoma histology on the frequency of bone metastases.

Methods This retrospective study evaluated the medical records of 407 patients diagnosed with lung cancer between 2003 and 2012. The prevalence of bone metastases and their association with histological subtypes were evaluated using chi-squared tests, odds ratios (ORs) and 95% confidence intervals (CIs). The overall survival was evaluated using the Kaplan-Meier method.

Results The prevalence of bone metastases was 28.2% (n = 115), and the spine was the most frequently affected site (98 metastases; 32.1%). Adenocarcinoma was the most common histological subtype of lung carcinoma (46.7%), and it was significantly more frequent among patients with bone metastases (58.3% versus 42.1%; p = 0.003; OR = 1.92; 95% CI: 1.29–2.97). Squamous cell carcinoma was significantly less frequent among patients with bone metastases (13.0% versus 29.8%; p = 0.0004; OR = 0.35; 95% CI: 0.19–0.64). The median survival time after the first bone metastasis diagnosis was 4 months.

Conclusion Adenocarcinoma was the most common histological subtype of lung carcinoma, and it was significantly associated with a higher risk of developing bone metastases.

Keywords

lung neoplasms - neoplasm metastasis - histology

* Work performed at Trauma and Orthopedics Service, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Originally published by Elsevier Ltda.


 

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