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Scheuermann, J.  et al.: 2024 Science of Synthesis, 2023/5: DNA-Encoded Libraries DOI: 10.1055/sos-SD-241-00269
DNA-Encoded Libraries

3.1 DNA-Templated Synthesis

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Buch

Herausgeber: Scheuermann, J. ; Li, Y. 

Autoren: Barluenga, S. ; Bassi, G. ; Brunschweiger, A. ; Cai, B. ; Cazzamalli, S. ; Chheda, P. ; Cui, M. ; Cui, W. ; Fang, X. ; Farrera-Soler, L. ; Favalli, N. ; Feng, J.; Foley, T. L. ; Franzini, R. M. ; Georgiev, T. ; Gillingham, D. ; Gloger, A. ; Graham, J. D. ; Granados, A. ; Heiden, S.; Hou, W. ; Huang, Y. ; Keefe, A. D. ; Krusemark, C. J. ; Li, X. ; Li, Y. ; Lin, W. ; Litovchick, A.; Liu, G. ; Lu, X. ; Lucaroni, L. ; Ma, P. ; Migliorini, F. ; Molander, G. A. ; Neri, D. ; Nie, Q. ; Oehler, S. ; Prati, L. ; Puglioli, S. ; Reddavide, F. V. ; Satz, A. L. ; Sauter, B. ; Scheuermann, J. ; Schuman, D.; Simmons, N. ; Stanway-Gordon, H. A. ; Su, W. ; Sun, J. ; Thompson, M.; Vummidi, B. R.; Wang, X. ; Wang, Y. ; Wang, Z. ; Waring, M. J. ; Willems, S.; Winssinger, N. ; Xia, B. ; Xiong, F. ; Xu, H. ; Xu, L. ; Yang, G. ; Zhang, G. ; Zhang, Y. ; Zhou, Y. 

Titel: DNA-Encoded Libraries

Print ISBN: 9783132455221; Online ISBN: 9783132437357; Buch-DOI: 10.1055/b000000342

1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Fachgebiete: Organische Chemie

Science of Synthesis Reference Libraries



Übergeordnete Publikation

Titel: Science of Synthesis

DOI: 10.1055/b-00000101

Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Typ: Mehrbändiges Werk

Auch verfügbar auf
 


Abstract

DNA-templated synthesis (DTS) represents a divergent strategy that harnesses the unique nature of DNA hybridization to achieve efficient library synthesis as well as encoding. By using base-pair hybridization to bring the DNA-linked reactants into intramolecular proximity and thus increase their effective local concentration for chemical reaction, DTS translates DNA sequences into the corresponding synthetic products, resembling Nature’s machinery of genetic-code translation. DTS can be applied to generate synthetic products chemically unrelated to the DNA backbone in a sequence-directed manner. Furthermore, a method that replaces the complex template pool with just a single DNA template is described, in which a novel “universal template” was designed to hybridize with multiple reagent DNA strands with different sequences. These properties allow the application of DTS to the programmed synthesis of large-scale DNA-encoded libraries.

Schlüsselwörter

DNA-encoded libraries - DNA-templated synthesis - DTS-based library synthesis - base-pair hybridization - macrocyclization - macrocycle library - universal template
 
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