Download PDF
Scheuermann, J.  et al.: 2024 Science of Synthesis, 2023/5: DNA-Encoded Libraries DOI: 10.1055/sos-SD-241-00242
DNA-Encoded Libraries

3.2.3.2 Natural-Product-Enriched DELs

More Information

Book

Editors: Scheuermann, J. ; Li, Y. 

Authors: Barluenga, S. ; Bassi, G. ; Brunschweiger, A. ; Cai, B. ; Cazzamalli, S. ; Chheda, P. ; Cui, M. ; Cui, W. ; Fang, X. ; Farrera-Soler, L. ; Favalli, N. ; Feng, J.; Foley, T. L. ; Franzini, R. M. ; Georgiev, T. ; Gillingham, D. ; Gloger, A. ; Graham, J. S. ; Granados, A. ; Heiden, S.; Hou, W. ; Huang, Y. ; Keefe, A. D. ; Krusemark, C. J. ; Li, X. ; Li, Y. ; Lin, W. ; Litovchick, A.; Liu, G. ; Lu, X. ; Lucaroni, L. ; Ma, P. ; Migliorini, F. ; Molander, G. A. ; Neri, D. ; Nie, Q. ; Oehler, S. ; Prati, L. ; Puglioli, S. ; Reddavide, F. V. ; Satz, A. L. ; Sauter, B. ; Scheuermann, J. ; Schuman, D.; Simmons, N. ; Stanway-Gordon, H. A. ; Su, W. ; Sun, J. ; Thompson, M.; Vummidi, B. R.; Wang, X. ; Wang, Y. ; Wang, Z. ; Waring, M. J. ; Willems, S.; Winssinger, N. ; Xia, B. ; Xiong, F. ; Xu, H. ; Xu, L. ; Yang, G. ; Zhang, G. ; Zhang, Y. ; Zhou, Y. 

Title: DNA-Encoded Libraries

Print ISBN: 9783132455221; Online ISBN: 9783132437357; Book DOI: 10.1055/b000000342

1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

Also available at
 


Abstract

Natural products are privileged compounds of natural evolution that are often rich in sp3 carbon atoms, bear multiple stereocenters, and have diverse skeletons. These features endow natural products with a broad spectrum of pharmacological activities. As a consequence, natural products play a key role in the history of medical treatment and drug discovery. The natural-product-enriched DNA-encoded library (nDEL) approach allows natural products or bioactive chemical molecules with known biological functions to be readily annotated with unique amplifiable DNA barcodes by so-called “late-stage” DNA labeling reactions. The final DNA-annotated natural products are included in a DEL, which can be packaged in a single test-tube and screened against a broad spectrum of cellular targets.

Key words

DNA-encoded libraries - natural products - drug discovery - labeling - screening
 
  • 1 Koch MA, Schuffenhauer A, Scheck M, Wetzel S, Casaulta M, Odermatt A, Ertl P, Waldmann H. Proc. Natl. Acad. Sci. U. S. A. 2005; 102: 17272
    Search in Google Scholar
  • 3 Ma P, Xu H, Li J, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Liu Z, Yang G, Lerner RA. Angew. Chem. Int. Ed. 2019; 58: 9254
    Search in Google Scholar
  • 4 Xu H, Ma P, In: DNA-Encoded Chemical Libraries Israel D, Ding Y. 2541. Humana New York 2022; 81-87
    Search in Google Scholar
  • 6 Liang J, Zhang L, Tan X.-L, Qi Y.-K, Feng S, Deng H, Yan Y, Zheng J.-S, Liu L, Tian C.-L. Angew. Chem. Int. Ed. 2017; 56: 2744
    Search in Google Scholar
  • 10 Wang S, Shi X, Li J, Huang Q, Ji Q, Yao Y, Wang T, Liu L, Ye M, Deng Y, Ma P, Xu H, Yang G. Adv. Sci. (Weinheim, Ger.) 2022; 9: 2201258
    Search in Google Scholar