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Scheuermann, J.  et al.: 2024 Science of Synthesis, 2023/5: DNA-Encoded Libraries DOI: 10.1055/sos-SD-241-00212
DNA-Encoded Libraries

3.2.2.2 Peptide Nucleic Acid (PNA) Encoded Libraries

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Book

Editors: Scheuermann, J. ; Li, Y. 

Authors: Barluenga, S. ; Bassi, G. ; Brunschweiger, A. ; Cai, B. ; Cazzamalli, S. ; Chheda, P. ; Cui, M. ; Cui, W. ; Fang, X. ; Farrera-Soler, L. ; Favalli, N. ; Feng, J.; Foley, T. L. ; Franzini, R. M. ; Georgiev, T. ; Gillingham, D. ; Gloger, A. ; Graham, J. D. ; Granados, A. ; Heiden, S.; Hou, W. ; Huang, Y. ; Keefe, A. D. ; Krusemark, C. J. ; Li, X. ; Li, Y. ; Lin, W. ; Litovchick, A.; Liu, G. ; Lu, X. ; Lucaroni, L. ; Ma, P. ; Migliorini, F. ; Molander, G. A. ; Neri, D. ; Nie, Q. ; Oehler, S. ; Prati, L. ; Puglioli, S. ; Reddavide, F. V. ; Satz, A. L. ; Sauter, B. ; Scheuermann, J. ; Schuman, D.; Simmons, N. ; Stanway-Gordon, H. A. ; Su, W. ; Sun, J. ; Thompson, M.; Vummidi, B. R.; Wang, X. ; Wang, Y. ; Wang, Z. ; Waring, M. J. ; Willems, S.; Winssinger, N. ; Xia, B. ; Xiong, F. ; Xu, H. ; Xu, L. ; Yang, G. ; Zhang, G. ; Zhang, Y. ; Zhou, Y. 

Title: DNA-Encoded Libraries

Print ISBN: 9783132455221; Online ISBN: 9783132437357; Book DOI: 10.1055/b000000342

1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

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Abstract

DNA-encoded libraries (DELs) have enabled the screening of dual-pharmacophore libraries but have thus far not allowed the recombination of those fragments after each round of selection. Herein we report the screening of suprabodies, a macromolecular PNA–DNA structure, which allow the shuffling of the library fragments after each round of selection. This technology has been applied to the discovery of new PD-L1 ligands.

Key words

DNA-encoded libraries - suprabody - screening - dual pharmacophores - evolution - recombination - peptide loop
 
  • 1 Melkko S, Scheuermann J, Dumelin CE, Neri D. Nat. Biotechnol. 2004; 22: 568
    PubMed
  • 2 Reddavide FV, Lin W, Lehnert S, Zhang Y. Angew. Chem. Int. Ed. 2015; 54: 7924
    PubMed
  • 3 Li G, Zheng W, Chen Z, Zhou Y, Liu Y, Yang J, Huang Y, Li X. Chem. Sci. 2015; 6: 7097
    PubMed
  • 4 Daguer J.-P, Zambaldo C, Ciobanu M, Morieux P, Barluenga S, Winssinger N. Chem. Sci. 2015; 6: 739
    PubMed
  • 5 Winssinger N, Gorska K, Ciobanu M, Daguer J.-P, Barluenga S, In: Peptide Nucleic Acids: Methods and Protocols Second Edition Nielsen PE, Appella DH. Humana Press Totowa, NJ 2014; 95
    Crossref
  • 6 Daguer J.-P, Gonse A, Shchukin Y, Farrera-Soler L, Barluenga S, Winssinger N. Bioorg. Med. Chem. 2021; 44: 116282
    PubMed
  • 7 Barluenga S, Zambaldo C, Ioannidou HA, Ciobanu M, Morieux P, Daguer J.-P, Winssinger N. Bioorg. Med. Chem. Lett. 2016; 26: 1080
  • 8 Novoa A, Machida T, Barluenga S, Imberty A, Winssinger N. ChemBioChem 2014; 15: 2058
    PubMed
  • 9 Sadhu KK, Winssinger N. Chimia 2013; 67: 905
    PubMed
  • 10 Zambaldo C, Barluenga S, Winssinger N. Curr. Opin. Chem. Biol. 2015; 26: 8
    PubMed
  • 11 Chouikhi D, Ciobanu M, Zambaldo C, Duplan V, Barluenga S, Winssinger N. Chem.–Eur. J. 2012; 18: 12698 Chem.–Eur. J. 2013; 19: 8022
  • 12 Machida T, Dutt S, Winssinger N. Angew. Chem. Int. Ed. 2016; 55: 8595
    PubMed
  • 13 Rapireddy S, Nhon L, Meehan RE, Franks J, Stolz DB, Tran D, Selsted ME, Ly DH. J. Am. Chem. Soc. 2012; 134: 4041
    PubMed
  • 14 Thurley S, Röglin L, Seitz O. J. Am. Chem. Soc. 2007; 129: 12693
    PubMed
  • 15 Vummidi BR, Farrera-Soler L, Daguer J.-P, Dockerill M, Barluenga S, Winssinger N. Nat. Chem. 2022; 14: 141
    PubMed