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Scheuermann, J.  et al.: 2024 Science of Synthesis, 2023/5: DNA-Encoded Libraries DOI: 10.1055/sos-SD-241-00187
DNA-Encoded Libraries

2.12 Micelle-Mediated Synthesis

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Book

Editors: Scheuermann, J. ; Li, Y. 

Authors: Barluenga, S. ; Bassi, G. ; Brunschweiger, A. ; Cai, B. ; Cazzamalli, S. ; Chheda, P. ; Cui, M. ; Cui, W. ; Fang, X. ; Farrera-Soler, L. ; Favalli, N. ; Feng, J.; Foley, T. L. ; Franzini, R. M. ; Georgiev, T. ; Gillingham, D. ; Gloger, A. ; Graham, J. S. ; Granados, A. ; Heiden, S.; Hou, W. ; Huang, Y. ; Keefe, A. D. ; Krusemark, C. J. ; Li, X. ; Li, Y. ; Lin, W. ; Litovchick, A.; Liu, G. ; Lu, X. ; Lucaroni, L. ; Ma, P. ; Migliorini, F. ; Molander, G. A. ; Neri, D. ; Nie, Q. ; Oehler, S. ; Prati, L. ; Puglioli, S. ; Reddavide, F. V. ; Satz, A. L. ; Sauter, B. ; Scheuermann, J. ; Schuman, D.; Simmons, N. ; Stanway-Gordon, H. A. ; Su, W. ; Sun, J. ; Thompson, M.; Vummidi, B. R.; Wang, X. ; Wang, Y. ; Wang, Z. ; Waring, M. J. ; Willems, S.; Winssinger, N. ; Xia, B. ; Xiong, F. ; Xu, H. ; Xu, L. ; Yang, G. ; Zhang, G. ; Zhang, Y. ; Zhou, Y. 

Title: DNA-Encoded Libraries

Print ISBN: 9783132455221; Online ISBN: 9783132437357; Book DOI: 10.1055/b000000342

1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

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Abstract

Solution-phase DNA-compatible chemistry has typically been restricted to aqueous media due to the solubility requirements of the oligonucleotide tag. This necessity has often limited the types of transformations that can be achieved within DNA-encoded libraries (DELs), and also the scope of building blocks that can be employed. Micelle-forming surfactants have been successfully employed within the field of green chemistry to allow for organic reactions to be conducted within aqueous systems. The application of such technologies for DNA-compatible chemistry thus shows significant promise in overcoming various issues previously exhibited in DEL synthesis, allowing for the generation of libraries with vastly improved chemical diversity. Reviewed herein are applications of micellar-mediated synthesis for DELs, including summaries of current methods for their construction. The implementation of this strategy allows for highly efficient transformations to be achieved across a broad range of substrates within each reaction class, marking an advantageous addition to on-DNA chemistry.

Key words

DNA-encoded libraries - DNA-compatible reactions - surfactants - micellar catalysis - palladium catalysis - cross-coupling reactions - acylation - amide-bond formation - amines - aromatic compounds - hydrogenation - hydrogenolysis - arenes
 
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