2.9 On-DNA Functional-Group Transformations
Buch
Herausgeber: Scheuermann, J. ; Li, Y.
Titel: DNA-Encoded Libraries
Print ISBN: 9783132455221; Online ISBN: 9783132437357; Buch-DOI: 10.1055/b000000342
1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Typ: Mehrbändiges Werk
Abstract
DNA-encoded libraries of small molecules typically access diverse chemical space via combinatorial coupling of building blocks and cores already bearing the requisite functional groups for the intended on-DNA synthetic sequence. However, on-DNA functional group transformations, wherein an on-DNA functional group is altered without the incorporation of a new diversity element, is a supplemental approach to expand the scope of on-DNA synthesis. This chapter reviews key on-DNA functional-group transformations for strategies such as the utilization of on-DNA protecting groups to enhance orthogonality, the in situ generation of commercially-rare or unstable on-DNA synthetic intermediates to enable extension of valuable core collections to alternative synthetic pathways, the employment of temporary functional groups as handles to regulate on-DNA chemical reactivity, and the encoding of specific functional groups into final library molecules.
Schlüsselwörter
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