2.5 On-DNA C—H Transformations
Book
Editors: Scheuermann, J. ; Li, Y.
Title: DNA-Encoded Libraries
Print ISBN: 9783132455221; Online ISBN: 9783132437357; Book DOI: 10.1055/b000000342
1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract
The C—H activation approach is a powerful strategy for synthesizing valuable building blocks and complex drug candidates via the direct formation of C—C and C—X bonds. There are several challenges in the development of DNA-compatible C—H functionalization reactions, including the high energy required to activate the inert C—H bonds, the need to tolerate water, and the need to preserve the integrity of oligonucleotides. In this chapter, we summarize the significant advances achieved in DNA-compatible C—H functionalization, including transition-metal-mediated reactions, photocatalyst-mediated reactions, and biocatalyst-mediated reactions, showcasing their detailed experimental protocols and substrate scopes.
Key words
DNA-encoded libraries - DNA-compatible reactions - C—H activation - transition-metal-mediated reactions - photocatalysis - biocatalysis - C—C bond formation - C—X bond formation- 2 Jardim GAM, De Carvalho RL, Nunes MP, Machado LA, Almeida LD, Bahou KA, Bower JF, Da Silva Júnior EN. Chem. Commun. (Cambridge) 2022; 58: 3101
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