2.2 Metal-Promoted DEL-Compatible C—C Bond Forming Reactions

Abstract

DNA-encoded library (DEL) technology relies on the availability of robust and DNA-compatible chemical transformations. Metal-promoted C—C bond forming reactions are widely applied for the synthesis of fine chemicals such as pharmaceuticals. However, their application in DEL technology represents a challenge due to the use of metal catalysts, high temperatures, and organic solvents. In this chapter, we report tailored conditions for the on-DNA application of the Suzuki, Sonogashira, Heck, and Giese reactions. The conditions presented in this chapter have been systematically explored across different DEL designs and structurally-diverse building blocks. By providing a comprehensive insight into the practical implementation of these metal-promoted C—C bond cross-coupling reactions, this review aims at expanding and promoting the application of these transformations in DEL construction.

Schlüsselwörter

DNA-encoded libraries - C—C bond formation - cross-coupling reactions - DEL synthesis - DNA-compatible reactions - Giese reaction - Heck reaction - Sonogashira coupling - Suzuki coupling - metal-catalyzed reactions

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