1.12 Nickel-Catalyzed Alkene Dicarbofunctionalization
Buch
Herausgeber: Yoshikai, N.
Titel: Base-Metal Catalysis 1
Print ISBN: 9783132453807; Online ISBN: 9783132453821; Buch-DOI: 10.1055/b000000441
1st edition © 2023 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Typ: Mehrbändiges Werk
Abstract

The transition-metal-catalyzed cross-coupling reactions of alkenyl compounds remain one of the most versatile ways of forming C—C bonds from organohalide and organometallic species. The application of inexpensive, readily available, and non-toxic base metals, such as nickel, as catalysts gives rise to a powerful approach to access highly substituted molecules via dicarbofunctionalization. A wide array of nucleophiles and/or electrophiles can be employed, and various mechanisms have been proposed. Generally, these mechanisms can be classified as redox-neutral, reductive, asymmetric, and photoredox dicarbofunctionalizations. In this chapter, we will highlight the recent advances made in the field of nickel-catalyzed alkene dicarbofunctionalization.
Schlüsselwörter
nickel catalysis - dicarbofunctionalization - alkenes - metallaphotoredox - photoredox catalysis - asymmetric catalysis - reductive coupling - two-component dicarbofunctionalization - three-component dicarbofunctionalization- 3 Qin T, Cornella J, Li C, Malins LR, Edwards JT, Kawamura S, Maxwell BD, Eastgate MD, Baran PS. Science (Washington, D. C.) 2016; 352: 801
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