1.11 Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions

Abstract

Nickel-catalyzed enantioselective reductive cross-coupling reactions enable simple and efficient synthesis of enantioenriched compounds, with high functionality tolerance, through circumventing the use of pregenerated organometallics. In this chapter, the most quintessential examples of the recent advances in this field have been summarized, and the contents are organized according to the reaction types.

Key words

nickel catalysis - reductive cross coupling - cross-electrophile coupling - asymmetric catalysis - ring-opening reactions - dicarbofunctionalization - Heck reaction - arylation - alkylation - carbamoylation - acylation - vinylation - organohalides - epoxides - aziridines - cyclobutanones - alkenes - oxindoles - indanes - indanones

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