1.6 Copper-Catalyzed Acidic C—H Functionalization

Abstract

Copper-catalyzed functionalization of acidic C—H bonds has emerged as a fruitful field due to the abundance and inexpensive nature of copper salts. In this chapter, we summarize the relevant advances in which copper promotes direct C—H functionalizations, including cross-dehydrogenative transformations, of activated organic substrates. The chapter is classified based on the types of activating group, including carbonyl, nitrile, nitro, as well as electron-deficient (hetero)aromatic groups.

Schlüsselwörter

copper catalysis - acidic C—H functionalization - carbonyl compounds - nitriles - nitroalkanes - polyfluoroarenes - hetarenes - cross-dehydrogenative coupling

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