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Bäckvall, J.-E. : 2023 Science of Synthesis, 2022/4: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) DOI: 10.1055/sos-SD-237-00121
Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)

10 Applications of Metal-Catalyzed Dynamic Kinetic Resolutions and Dynamic Kinetic Asymmetric Transformations for the Synthesis of Complex Molecules

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Buch

Herausgeber: Bäckvall, J.-E. 

Autoren: Adriaensen, K. ; Akai, S. ; Berreur, J. ; Bhat, V. ; Clayden, J. ; Collins, B. S. L. ; Córdova, A. ; De Vos, D. ; Deiana, L.; Faber, K. ; Fletcher, S. P. ; Goetzke, F. W. ; González-Granda, S. ; Gotor-Fernández, V. ; Hafeman, N. J. ; Jin, Z. ; Kanomata, K. ; Kroutil, W. ; Liu, Y.; Modicom, F.; Pàmies, O. ; Sardini, Jr., S. R.; Stoltz, B. M. ; Winkler, C. K. ; Wu, X. ; Xie, J.-H. ; Zhang, K.; Zhou, Q.-L. 

Titel: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)

Print ISBN: 9783132453777; Online ISBN: 9783132453791; Buch-DOI: 10.1055/b000000439

1st edition © 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie

Science of Synthesis Reference Libraries



Übergeordnete Publikation

Titel: Science of Synthesis

DOI: 10.1055/b-00000101

Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Typ: Mehrbändiges Werk

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Abstract

The stereocontrolled synthesis of complex molecules is a key technology for the pharmaceutical, agrochemical, and fine-chemical industries, a well-established field of organic chemistry, and the ultimate proving ground for the value of newly developed synthetic methods. This chapter illustrates how metal-catalyzed dynamic kinetic resolutions (DKR) and dynamic kinetic asymmetric transformations (DYKAT) have been used in the synthesis of complex molecules such as natural products, pharmaceuticals, and chiral ligands. This approach has unique strategic advantages over other methods as it allows the use of racemic starting materials, where asymmetry is introduced at a later stage in a synthetic sequence and can even be used to set multiple stereogenic centers in a single step.

Schlüsselwörter

asymmetric catalysis - dynamic kinetic resolution - dynamic kinetic asymmetric transformation - DKR - DYKAT - natural products - pharmaceuticals - total synthesis - transition metals - isomerization - resolution - racemic starting materials - hydrogenation - reduction - cross coupling - stereochemical arrays - allylic substitution
 
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