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Jamison, T. F. et al.: 2018 Science of Synthesis, 2018/5: Flow Chemistry in Organic Synthesis DOI: 10.1055/sos-SD-228-00173
Flow Chemistry in Organic Synthesis

8 Gaseous Reagents in Continuous-Flow Synthesis

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Book

Editors: Jamison, T. F.; Koch, G.

Authors: Beeler, A. B.; Beingessner, R. L.; Bottecchia, C.; Browne, D. L.; Coley, C. W.; Ferguson, S.; Folgueiras-Amador, A. A.; Gilmore, K.; Hicklin, R. W.; Imbrogno, J.; Itsuno, S.; Jamison, T. F.; Jensen, K. F.; Kelly, L. P.; Kerr, M. S.; Kiesman, W. F.; Kim, H.; Kwok, D.-I. A.; Ley, S. V.; Longstreet, A. R.; May, S. A.; McTeague, T. A.; Mijalis, A. J.; Mo, Y.; Moon, S.; Myerson, A.; Noël, T.; O’Brien, A. G.; O’Brien, M.; O’Mahony, M.; Opalka, S. M.; Pentelute, B. L.; Polyzos, A.; Schepartz, A.; Seeberger, P. H.; Seo, H.; Steinauer, A.; Stelzer, T.; Stephenson, C. R. J.; Strom, A. E.; Styduhar, E. D.; Sun, A. C.; Telmesani, R.; Thomas, D. A.; Tran, T. H.; Ullah, M. S.; Wicker, A. C.; Wirth, T.; Yoshida, J.

Title: Flow Chemistry in Organic Synthesis

Print ISBN: 9783132423312; Online ISBN: 9783132423350; Book DOI: 10.1055/b-006-161272

1st edition © 2018. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

Also available at
 


Abstract

Although reactive gases facilitate a wide range of important synthetic transformations, their use is often not straightforward. Significant safety issues arise from the highly mobile nature of gases, both in terms of the rapidity with which they can spread throughout the laboratory and also because of the frequent need to use pressurized containment. Additionally, as surface-area-to-volume ratios tend to decrease as reactor dimensions are increased, gas–liquid transformations carried out in batch mode are often accompanied by scale-dependent performance. This chapter highlights some of the benefits that continuous flow chemistry can bring to gas–liquid synthetic chemistry. A number of flow chemical reactor systems are described, including microfluidic devices which enhance the mechanical mixing of gas and liquid phases, as well as systems based on the use of gas-permeable membrane materials.

Key words

gas–liquid - flow chemistry - falling film - cyclone - H-Cube - Teflon AF-2400 - tube-in-tube - biphasic flow - microfluidic - membranes
 
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