1.4. 1 Peroxy Radical Additions
Book
Editor: Snyder, S. A.
Title: Applications of Domino Transformations in Organic Synthesis 1
Print ISBN: 9783131731319; Online ISBN: 9783132402522; Book DOI: 10.1055/b-003-128286
1st edition © 2016. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract
In this chapter, radical addition reactions involving peroxy radical intermediates are reviewed. These transformations typically generate a carbon radical intermediate which then reacts with molecular oxygen forming a peroxy radical species. Following peroxy radical cyclization, various endoperoxide rings are constructed. Two major classes of reactions are discussed: (1) radical additions to alkenes and quenching with molecular oxygen, and (2) radical formation from the opening of cyclopropanes and incorporation of molecular oxygen. Various methods for radical initiation that are compatible with the presence of molecular oxygen are described.
Key words
peroxide synthesis - endoperoxides - cyclic peroxides - radical addition - peroxy radicals - thiyl radicals - hydroperoxidation - cyclopropane cleavage - 1,2-dioxolanes - 1,2-dioxanes - 1,2-dioxepanes- 3 Korshin EE, Bachi MD. Synthesis of Cyclic Peroxides, Pataiʼs Chemistry of Functional Groups (Online). Wiley New York 2009; pp 1–117
- 5 Zabicky J, In The Chemistry of the Peroxide Group. Rappoport Z. Wiley; Chichester, UK 2006. Part 2, Vol. 2, pp 597–773.
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