2.2 C—C Bond Formation by Alkyl C—H Activation
Buch
Herausgeber: Yu, J.-Q.
Titel: Catalytic Transformations via C-H Activation 2
Print ISBN: 9783132057210; Online ISBN: 9783132404137; Buch-DOI: 10.1055/b-004-129675
1st edition © 2015 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Typ: Mehrbändiges Werk
Abstract

In comparison to the wealth of methods recently developed for the catalytic functionalization of the C(sp2)—H bonds of arenes and hetarenes, relatively little work has focused on the functionalization of the unactivated C(sp3)—H bonds of alkyl fragments. This chapter highlights selected examples of the fast-growing literature on the catalytic functionalization of unactivated C(sp3)—H bonds through organometallic C—H activation, with an emphasis on the most synthetically useful methods. It covers heteroatom-directed C(sp3)—H activation with regard to cross coupling with alkenes, alkynes, and carbon monoxide, organoboron reagents, diaryliodonium salts, and organic halides. Also included is C(sp3)—H activation/intramolecular C—C coupling induced by oxidative addition and nondirected intermolecular C(sp3)—H arylation.
Schlüsselwörter
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