Yu, J.-Q.: 2015 Science of Synthesis, 3b: Catalytic Transformations via C-H Activation 2 DOI: 10.1055/sos-SD-218-00014
Catalytic Transformations via C—H Activation 2

2.2 C—C Bond Formation by Alkyl C—H Activation

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Buch

Herausgeber: Yu, J.-Q.

Autoren: Carreira, E. M.; Decicco, C. P.; Fuerstner, A.; Koch, G.; Molander, G. A.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.

Titel: Catalytic Transformations via C-H Activation 2

Print ISBN: 9783132057210; Online ISBN: 9783132404137; Buch-DOI: 10.1055/b-004-129675

Fachgebiete: Organische Chemie

Science of Synthesis Reference Libraries



Übergeordnete Publikation

Titel: Science of Synthesis

DOI: 10.1055/b-00000101

Typ: Mehrbändiges Werk

 


Abstract

In comparison to the wealth of methods recently developed for the catalytic functionalization of the C(sp2)—H bonds of arenes and hetarenes, relatively little work has focused on the functionalization of the unactivated C(sp3)—H bonds of alkyl fragments. This chapter highlights selected examples of the fast-growing literature on the catalytic functionalization of unactivated C(sp3)—H bonds through organometallic C—H activation, with an emphasis on the most synthetically useful methods. It covers heteroatom-directed C(sp3)—H activation with regard to cross coupling with alkenes, alkynes, and carbon monoxide, organoboron reagents, diaryliodonium salts, and organic halides. Also included is C(sp3)—H activation/intramolecular C—C coupling induced by oxidative addition and nondirected intermolecular C(sp3)—H arylation.

 
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