1.1. 7 Metal-Catalyzed C—H Alkylation Using RX Compounds
Book
Editor: Yu, J.-Q.
Title: Catalytic Transformations via C—H Activation 1
Subtitle: C-C, C-N, C-O, C-Hal, and C-B Bond Formation
Print ISBN: 9783131711311; Online ISBN: 9783132403413; Book DOI: 10.1055/b-003-129295
1st edition © 2016 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Type: Multivolume Edition
Abstract
![](https://www.thieme-connect.de/media/10.1055-b-003-129295/thumbnails/a_208yjh.jpg)
This review covers transition-metal-catalyzed C(sp2)—H alkylation methods via carbon—heteroatom bond cleavage. The first part of the review delineates catalytic C(sp2)—H alkylation methods for arene and alkene substrates using various alkyl halides. Subsequently, alkylation by cleavage of C—B, C—Si, and C—Sn bonds is described. Finally, C(sp2)—H alkylation via C—O and C—S bond cleavage is reviewed.
Key words
alkylation - C—H activation - arenes - alkenes - transition-metal catalysts- 1 Roberts RM, Khalaf AA. Friedel–Crafts Alkylation Chemistry: A Century of Discovery. Dekker; New York 1984
- 2 Olah GA, Krishnamurti R, Prakash GKS, Comprehensive Organic Synthesis. Trost BM, Fleming I. Pergamon; Oxford 1991. 3.
- 6 van Putten R.-J, van der Waal JC, de Jong E, Rasrendra CB, Heeres HJ, de Vries JG. Chem. Rev. 2013; 113: 1499
- 10 Murai S, Kakiuchi F, Sekine S, Tanaka Y, Kamatani A, Sonoda M, Chatani N. Nature (London) 1993; 366: 529
- 38 Giri R, Maugel N, Li J.-J, Wang D.-H, Breazzano SP, Saunders LB, Yu J.-Q. J. Am. Chem. Soc. 2007; 129: 3510