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Faber, K. et al.: 2015 Science of Synthesis: Biocatalysis in Organic Synthesis 3 DOI: 10.1055/sos-SD-216-00397
Biocatalysis in Organic Synthesis 3

3.11 Creation and Optimization of Artificial Enzymes for Abiological Reactions

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Editors: Faber, K.; Fessner, W.-D.; Turner, N. J.

Authors: Allen, C. C. R.; de Gonzalo, G.; Ellinger, J. J.; Ewing, T. A.; Faber, K.; Fernández-Lucas, J.; Flynn, C. M.; Fraaije, M. W.; García-Junceda, E.; Garrabou, X.; Gkotsi, D. S.; Glueck, S. M.; Goss, R. J. M.; Grogan, G.; Gröger, H.; Grüschow, S.; Hammer, S. C.; Hauer, B.; Herter, S.; Hilvert, D.; Hollmann, F.; Hormigo, D.; Hummel, W.; Molla, G.; Nestl, B. M.; Nolte, J. C.; Obexer, R.; Oroz-Guinea, I.; Patel, R. N.; Pollegioni, L.; Quin, M. B.; Schmidt-Dannert, C.; Smith, D. R. M.; Turner, N. J.; Urlacher, V. B.; van Berkel, W. J. H.; Woodley, J. M.

Title: Biocatalysis in Organic Synthesis 3

Print ISBN: 9783131746610; Online ISBN: 9783131974914; Book DOI: 10.1055/b-003-125814

1st edition © 2015. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Type: Multivolume Edition

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Abstract

Catalytic antibody technology and computational design represent conceptually distinct strategies to artificial enzymes. Both approaches provide significant activities and tailored specificities for mechanistically distinct transformations, including abiological and asymmetric reactions. This review compares the relative strengths and limitations of such de novo catalysts, delineating challenges to overcome in the pursuit of synthetically useful enzymes for any given chemical transformation.

Key words

catalytic antibodies - computational design - directed evolution - Diels–Alder reaction - Kemp elimination - (retro-)aldol reaction - ester hydrolysis - metalloenzymes - computational redesign
 
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