3.10 Emerging Enzymes
Book
Editors: Faber, K.; Fessner, W.-D.; Turner, N. J.
Title: Biocatalysis in Organic Synthesis 3
Print ISBN: 9783131746610; Online ISBN: 9783131974914; Book DOI: 10.1055/b-003-125814
1st edition © 2015. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Type: Multivolume Edition
Abstract
Nature has developed and adapted a large number of enzyme types. Remarkably, these enzymes may be further used in biocatalysis for synthetic purposes. This chapter provides an overview of emerging cases of novel enzymes. Herein, nitrile reductases, sulfatases, squalene hopene cyclases, and aldoxime dehydratases may provide very powerful novel synthetic approaches in the futures, as they catalyze chemically interesting reactions under very mild reaction conditions and with high selectivities. These biocatalysts comprise a broad field of options, whereby biocatalysis may contribute to the quest for novel chemistry for future applications.
Key words
emerging enzymes - nitrile reductase - inverting and retaining sulfatase - squalene hopene cyclase - aldoxime dehydratase- 4 Barrett AGM, Comprehensive Organic Synthesis. Trost BM, Fleming I. Pergamon; Oxford 1991. 8. 251–254
- 8 Van Lanen SG, Reader JS, Swairjo MA, de Crécy-Lagard V, Lee B, Iwata-Reuyl D. Proc. Natl. Acad. Sci. U. S. A. 2005; 102: 4264
- 10 Wilding B, Winkler M, Petschacher B, Kratzer R, Glieder A, Klempier N. Adv. Synth. Catal. 2012; 354: 2191
- 11 Wilding B, Winkler M, Petschacher B, Kratzer R, Egger S, Steinkellner G, Lyskowski A, Nidetzky B, Gruber K, Klempier N. Chem.–Eur. J. 2013; 19: 7007
- 14 Swairjo MA, Reddy RR, Lee B, Van Lanen SG, Brown S, de Crécy-Lagard V, Iwata-Reuyl D, Schimmel P. Acta Crystallogr., Sect. F 2005; 61: 945
- 15 Chikwana VM, Stec B, Lee BWK, de Crécy-Lagard V, Iwata-Reuyl D, Swairjo MA. J. Biol. Chem. 2012; 287: 30560
- 23 Knaus T, Schober M, Kepplinger B, Faccinelli M, Pitzer J, Faber K, Macheroux P, Wagner U. FEBS J. 2012; 279: 4374
- 24 Bornscheuer UT, Kazlauskas RJ. Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations. Wiley-VCH; Weinheim, Germany 2006
- 25 Lukatela G, Krauss N, Theis K, Selmer T, Gieselmann V, von Figura K, Saenger W. Biochemistry 1998; 37: 3654
- 26 Boltes I, Czapinska H, Kahnert A, von Bülow R, Dierks T, Schmidt B, von Figura K, Kertesz MA, Usón I. Structure (Oxford, U. K.) 2001; 9: 483
- 27 Hagelueken G, Adams TM, Wiehlmann L, Widow U, Kolmar H, Tümmler B, Heinz DW, Schubert W.-D. Proc. Natl. Acad. Sci. U. S. A. 2006; 103: 7631
- 28 Schober M, Gadler P, Knaus T, Kayer H, Birner-Grünberger R, Gülly C, Macheroux P, Wagner U, Faber K. Org. Lett. 2011; 13: 4296
- 30 Schober M, Toesch M, Knaus T, Strohmeier GA, van Loo B, Fuchs M, Hollfelder F, Macheroux P, Faber K. Angew. Chem. Int. Ed. 2013; 52: 3277
- 33 Bringmann G, Günther C, Ochse M, Schupp O, Tasler S, Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Herz W, Falk H, Kirby GW, Moore RE. Springer; Vienna, Austria 2001. 82. 1
- 37 Gil GC, Fisch KM, Heinekamp T, Günther S, Hüttel W, Piel J, Brakhage AA, Müller M. Angew. Chem. Int. Ed. 2012; 51: 9788
- 38 Nozawa K, Seyea H, Nakajima S, Udagawa S.-i, Kawai K.-i. J. Chem. Soc., Perkin Trans. 1 1987; 1735
- 42 Präg A, Grüning BA, Häckh M, Lüdeke S, Wilde M, Luzhetskyy A, Richter M, Luzhetska M, Günther S, Müller M. J. Am. Chem. Soc. 2014; 136: 6195
- 63 Sibbesen O, Koch B, Rouzé P, Møller BL, Halkier BA, Amino Acids and Their Derivatives in Higher Plants. Wallsgrove RM. Cambridge University Press; Cambridge, UK 1995: 227