1.4.4 Enzymatic Synthesis of Amides

J. W. Schmidberger; L. J. Hepworth; A. P. Green; S. L. Flitsch

Abstract

The synthesis of amides is one of the most common reactions performed in organic chemistry. Biocatalysis is an attractive alternative to chemical methodologies because of the mild reaction conditions and excellent atom economy, combined with the potential for stereoselectivity. Here, we provide an overview of the literature on enzyme-catalyzed amide-bond formation on a preparative scale, with a focus on nonnatural substrates.

Schlüsselwörter

amines - amides - esters - aminolysis - enzymes - regioselectivity - chemoselectivity - stereoselectivity - kinetic resolution - lipases - esterases - penicillin acylases - proteases - nitrile hydratases

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