Faber, K. et al.: 2015 Science of Synthesis, 1: Biocatalysis in Organic Synthesis 1 DOI: 10.1055/sos-SD-214-00071
Biocatalysis in Organic Synthesis 1

1.2 Strategies and Methods in Biocatalysis

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Book

Editors: Faber, K.; Fessner, W.-D.; Turner, N. J.

Authors: Asano, Y.; Babich, L.; Bertau, M.; Cobucci-Ponzano, B.; Díaz-Rodríguez, A.; Engel, U.; Faber, K.; Flitsch, S. L.; Glueck, S. M.; Gotor-Fernández, V.; Green, A. P.; Hall, M.; Hartog, A. F.; Hepworth, L. J.; Hollmann, F.; Jeromin, G. E.; Lauchli, R.; Lavandera, I.; Liese, A.; Martínková, L.; Moracci, M.; Pesci, L.; Rodríguez-Mata, M.; Rozzell, D.; Rudat, J.; Schmidberger, J. W.; Servi, S.; Slomka, C.; Syldatk, C.; Tasnádi, G.; Tessaro, D.; Veselá, A. B.; Voglmeir, J.; Wever, R.

Title: Biocatalysis in Organic Synthesis 1

Print ISBN: 9783131741318; Online ISBN: 9783131975218; Book DOI: 10.1055/b-003-125815

Subjects: Organic Chemistry

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Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Type: Multivolume Edition


Abstract

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The use of biocatalysts in organic synthesis and, particularly, in the preparation of optically pure chemicals offers major advantages in terms of selectivity, efficiency, safety, and sustainability. Thus, research groups are becoming more interested in biocatalysis as a tool for challenging synthetic routes. Herein we focus on the different strategies and methods that chemists have designed in order to obtain enantioenriched compounds starting from prochiral or racemic derivatives using enzymes or whole cells as catalysts. In the first part of the chapter, enzymatic desymmetrizations are presented, followed by other established systems dealing with racemates to attain a single or two enantiopure derivatives in the same reaction vessel. Then, the preparation of optically pure compounds in excellent yields and enantiomeric excesses by means of deracemization techniques is discussed. Finally, some recent examples where the combination of enzymes with other (bio)catalysts has provided high-added-value targets are shown.