2.6 Metal-Mediated Multicomponent Reactions

C. Xi; C. Chen

Abstract

Multicomponent reactions (MCRs) make possible the rapid synthesis of molecular libraries that have a high degree of structural diversity. Metal-mediated multicomponent reactions are particularly interesting as they give access to processes that occur with high chemo-, regio-, and stereoselectivity with excellent functional group tolerance. For example, reductive coupling of two unsaturated compounds on reduced zirconocene affords a variety of zirconacycles, which react with electrophiles to form various carbo- and heterocycles.

Key words

carbene complexes - chemoselectivity - C—M bonds - main group metals - metallacycles - regioselectivity - stereoselectivity - stoichiometric reactions - transition metals

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