2.3 Boron-Mediated Multicomponent Reactions
Book
Editor: Müller, T. J. J.
Title: Multicomponent Reactions, Volume 2
Subtitle: Reactions Involving an α,α-Unsaturated Carbonyl Compound as Electrophilic Component, Cycloadditions, and Boron-, Silicon-, Free-Radical-, and Metal-Mediated Reactions
Print ISBN: 9783131728319; Online ISBN: 9783132064317; Book DOI: 10.1055/b-003-125831
1st edition © 2014. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Multicomponent Reactions
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract
Organoboronates are important reagents in modern synthetic applications. However, some organoboronates are unstable or difficult to purify. A possible solution is to perform organic transformations with in situ generated organoboronates. The organoboronates react selectively with many substrates, such as carbonyl compounds (allylation reactions) or organohalides (Suzuki–Miyaura coupling). Furthermore, synthesis of organoboronates and the subsequent transformations can be easily combined in the same reaction vessel. This chapter presents examples of these reactions including generation of organoboronates from simple prefunctionalized substrates (such as alcohols) and via C—H functionalization processes.
Key words
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