18.15.8 Tetraheterosubstituted Methanes with a Carbon—Halogen Bond (Update 2018)

Abstract

In this chapter, recent methods for the preparation and elaboration of various substituted halomethanes are summarized. In addition to updates on classical methods, recently developed procedures employing new fluorinating agents, such as Togni’s reagents, are also presented. These methods are also put in the context of the synthesis of biologically active compounds.

Key words

trifluoromethylation - trifluoromethylsulfanylation - Togni’s reagents - Selectfluor - tetrahalomethanes - Umemoto’s reagent - Ruppert–Prakash reagent - PhenoFluor - trifluoromethylselanylation

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