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Christmann, M. et al.: 2020 Science of Synthesis, 2020/1: Knowledge Updates 2020/1 DOI: 10.1055/sos-SD-116-01081
Knowledge Updates 2020/1

16.17.7 Purines (Update 2020)

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Editors: Christmann, M.; Huang, Z.; Jiang, X.; Li, J.-J.; Oestreich, M.; Petersson, E. J.; Schaumann, E.; Wang, M.

Authors: Bode, J. W.; Cabrera, M.; Howlader, A. H.; Huang, Z.; Liang, Y.; Liu, G.; Maison, W.; Ohe, K.; Okamoto, K.; Osuna Gálvez, A.; Wen, Z.; Wnuk, S. F.; Wu, F.; Zhu, S.

Title: Knowledge Updates 2020/1

Print ISBN: 9783132435582; Online ISBN: 9783132435605; Book DOI: 10.1055/b000000102

1st edition © 2020 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

Science of Synthesis Knowledge Updates



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

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Abstract

This chapter is an update to the earlier Science of Synthesis contribution (Section 16.17) describing methods for the synthesis and chemical modification of purine and purine derivatives. It focuses on the literature published in the period 2002–2019, with a particular emphasis on regioselective direct C—H functionalization of purines, transition-metal-catalyzed cross-coupling reactions of halopurines, and synthesis of purine analogues, including azidopurines, by exchange of substituents.

Key words

adenines - alkenylation - alkylation - alkynylation - amination - arylation - azidopurines - Buchwald–Hartwig reaction - carbon–carbon coupling - C-H bond activation - click reactions - cross-coupling reactions - cyclization - double C-H activation - fluorination - fused purines - guanines - halogen-exchange reactions - halogenation - halopurines - hypoxanthines - imidazoles - Negishi coupling - nucleosides - organometallic reagents - palladium catalysts - purines - pyrimidines - radical reactions - ring closure - Sonogashira coupling - Stille coupling - Suzuki–Miyaura coupling - transition metals
 
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