Antifungal Saponins from Paris polyphylla Smith

Abstract

Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as (25R)-spirost-5-ene-3β,17α-diol (pennogenin) 3-O-{O-α-L-rhamnopyranosyl-(1→2)-O-[O-β-xylopyranosyl-(1→5)-α-L-arabinofuranosyl-(1→4)]-β-D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products.

Key words

saponins - pennogenin - Liliaceae - Paris polyphylla - antifungal activity

References

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