Synlett 2007(5): 0790-0794  
DOI: 10.1055/s-2007-970754
LETTER
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Iridium-Catalyzed Allylic Alkylations - Improvements and Applications Based on Salt-Free Reaction Conditions

Christian Gnamm, Sebastian Förster, Nicole Miller, Kerstin Brödner, Günter Helmchen*
Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
Fax: +49(6221)544205; e-Mail: g.helmchen@oci.uni-heidelberg.de;
Further Information

Publication History

Received 5 January 2007
Publication Date:
08 March 2007 (online)

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Abstract

Simplified procedures for the Ir-catalyzed asymmetric allylic alkylation reaction are described that often allow substitution products to be obtained with ≥99% ee. Applications to syntheses of important chiral building blocks, such as the Taniguchi lactone and dimethyl 2-vinylcyclopropane-1,1-dicarboxylate, are presented.