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Synlett 2008(2): 217-220  
DOI: 10.1055/s-2007-1000871
LETTER
© Georg Thieme Verlag Stuttgart · New York

Iodoarene-Mediated One-Pot Preparation of 2,4,5-Trisubstituted Oxazoles from Ketones

Yuhta Kawano, Hideo Togo*
Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku Chiba 263-8522, Japan
e-Mail: togo@faculty.chiba-u.jp;
Further Information

Publication History

Received 24 October 2007
Publication Date:
21 December 2007 (online)

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Abstract

2-Methyl-5-aryloxazole and 2-ethyl-5-aryloxazole derivatives were smoothly and efficiently obtained in one-pot manner from alkyl aryl ketones with iodoarene, m-chloroperbenzoic acid, and trifluoromethanesulfonic acid in acetonitrile and propionitrile, respectively. In these reactions, iodoarene works as a catalyst.

Key words

2,4,5-trisubstituted oxazoles - one-pot reaction - MCPBA - iodoarene

    References and Notes

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