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Synthesis 1993; 1993(6): 568-570
DOI: 10.1055/s-1993-25905
short paper
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Synthesis of 3-Aminopyrrolo[2,1-a]isoquinoline, 3-Aminopyrrolo[2,1-a]phthalazine, and 7-Aminopyrrolo[1,2-b]pyridazine Derivatives

Alexander F. Khlebnikov* , Elena I. Kostik, Raphael R. Kostikov
  • *Department of Chemistry, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russia
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Publication Date:
17 September 2002 (online)

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A simple route to 3-aminopyrrolo[2,1-a]isoquinoline, 3-aminopyrrolo[2,1-a]phthalazine, and 7-aminopyrrolo[1, 2-b]pyridazine derivatives 8a, 8b and 11, respectively, is described, based on displacement of a chlorine atom in the appropriate precursors with benzylamine. The chloro-substituted precursors were prepared by using a tandem dichlorocarbene/cycloimmonium ylide approach.