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Thromb Haemost 2000; 83(04): 589-591
DOI: 10.1055/s-0037-1613868
DOI: 10.1055/s-0037-1613868
Commentary
The Thrombogram: Monitoring Thrombin Generation in Platelet Rich Plasma
Further Information
Publication History
Received
20 July 1999
Accepted after revision
23 November 1999
Publication Date:
08 December 2017 (online)


Summary
A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.