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DOI: 10.1055/s-0037-1609152
Aminocarbonylation of N-Containing Heterocycles with Aromatic Amines Using Mo(CO)6
French program ‘Investissement d’Avenir – Institut Carnot’ managed by the National Research Agency (ANR-11-CARN-008-01).Publication History
Received: 13 December 2017
Accepted after revision: 13 December 2017
Publication Date:
18 January 2018 (online)


Abstract
We describe herein the palladium-catalyzed aminocarbonylation of nitrogen-containing heterocycles with aniline derivatives using molybdenum hexacarbonyl as a CO solid source, expanding the scope of the limited examples. This method is compatible with a variety of substitutions on the aniline moiety. The simple reaction conditions include easily available Pd(dppf)Cl2 catalyst, DBU as base in DMF at 120 °C for 3 hours in sealed tube thereby leading to the isolation of 21 compounds with yields ranging from 18 to 82%. We also show that double aminocarbonylation reactions are possible in satisfactory yields regarding both coupling partners.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609152.
- Supporting Information