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Synthesis 2011(4): 642-652
DOI: 10.1055/s-0030-1258399
DOI: 10.1055/s-0030-1258399
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
On the Synthesis of Arylpropiolic Acids and Investigations towards the Formation of Vinyl Chlorides by HCl Addition During Esterification Reactions
Weitere Informationen
Received
16 November 2010
Publikationsdatum:
10. Januar 2011 (online)
Publikationsverlauf
Publikationsdatum:
10. Januar 2011 (online)

Abstract
The synthesis protocol for the preparation of different arylpropiolic acids using the Negishi reaction and the addition of HCl to the alkyne moiety of these acids in subsequent esterification reactions using SOCl2 was examined.
Key words
alkynes - esterification - addition reactions - vinyl chlorides - Negishi reaction
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1a
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The crystallographic data for compound 6 have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication CCDC 797405. Copies of the data can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44(1223)336033; e-mail: deposit@ccdc.cam.ac.uk].