Synthesis 2022; 54(03): 697-704
DOI: 10.1055/a-1652-3370
paper

Oxidation of α,β-Unsaturated Ketones by Organophotocatalysis Using Rhodamine 6G under Visible Light Irradiation: Insight into the Reaction Mechanism

Eito Yoshioka
,
Hiroki Takahashi
,
Hikari Wanibe
,
Yukina Hontani
,
Kouki Hatsuse
,
Remi Shimizu
,
Akira Kawashima
,
Shigeru Kohtani
,
Hideto Miyabe
This work was supported by a Japan Society for the Promotion of Science (JSPS) KAKENHI Grant-in-Aid for Scientific Research (C) (Grant Number 20K06954, to H.M.).


Abstract

The oxidative transformation of α,β-unsaturated ketones was investigated under visible-light-induced photocatalytic conditions using rhodamine 6G as an organophotocatalyst. In this organocatalysis, the mild co-oxidant bromotrichloromethane (BrCCl3) acts not only as a quencher toward the activated photocatalyst species, having reductant properties, but also as a brominating reagent for the intermediate radicals. This study shows that bromine atom transfer from BrCCl3 to intermediate radicals is a key step in the reaction mechanism of our oxidation method.

Supporting Information



Publication History

Received: 08 September 2021

Accepted after revision: 23 September 2021

Accepted Manuscript online:
23 September 2021

Article published online:
26 October 2021

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