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Horm Metab Res 2020; 52(06): 448-453
DOI: 10.1055/a-1157-0511
Review

The Effect of Extracellular Calcium Metabolism on Aldosterone Biosynthesis in Physiological and Pathological Status

Xin Gao
1   Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
,
Yuto Yamazaki
1   Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
,
Yuta Tezuka
2   Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan
3   Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai, Japan
,
Kei Omata
2   Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan
3   Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai, Japan
,
Yoshikiyo Ono
3   Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai, Japan
,
Ryo Morimoto
3   Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai, Japan
,
Yasuhiro Nakamura
4   Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
,
Fumitoshi Satoh
2   Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan
3   Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai, Japan
,
Hironobu Sasano
1   Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
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Abstract

Primary aldosteronism (PA) was reported to frequently harbor not only cardiovascular diseases but also some metabolic disorders including secondary calcium metabolic diseases. Recently, the potential association between aldosterone producing cells and systemic calcium metabolism has been proposed. For instance, PA is frequently associated with hypercalciuria or hypocalcemia, which subsequently stimulates parathyroid hormone (PTH) secretion. This altered calcium metabolism in PA patients could frequently result in secondary osteoporosis and fracture in some patients. On the other hand, extracellular calcium itself directly acts on adrenal cortex and has been also proposed as an independent regulator of aldosterone biosynthesis in human adrenals. However, it is also true that both PTH and vitamin D pathways stimulate endocrine functions of adrenal cortical adenomas to co-secret both aldosterone and cortisol. Therefore, it has become pivotal to explore the potential crosstalk between aldosterone and systemic calcium metabolism. We herein reviewed recent advances in these fields.

Key words

adrenal cortex - aldosterone - calcium - vitamin D


Publication History

Received: 30 November 2019

Accepted: 30 March 2020

Article published online:
13 May 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 

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