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Planta Med 1986; 52(1): 38-41
DOI: 10.1055/s-2007-969063
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© Georg Thieme Verlag Stuttgart · New York

Biologically Active Macrocyclic Diterpenoids from Chinese Drug “Fáng Féng Cáo” I. Isolation and Structure1

M. Arisawa2 , M. Nimura2 , A. Ikeda2 , T. Hayashi2 , N. Morita2 , Y. Momose3 , R. Takeda3 , S. Nakanishi3
  • 2Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-01, Japan
  • 3Faculty of Medicine, Toyama Medical and Pharmaceutical University
1 A part of this data was first presented at the 31st Annual Meeting of the Japanese Society of Pharmacognosy, Tokyo, October, 1984
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Publikationsverlauf

1985

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

Three novel macrocyclic diterpepoids, 4,7-oxycycloanisomelic acid (4), 4-methylene-5-hydroxyovatodiolode (5) and 4-methylene-5-oxoanisomelic acid (6) were isolated from the dried whole plant of the Chinese crude drug Fáng Féng Cáo (Anisomeles indica, Labiatae), together with ovatodiolide (1), 4, 5-epoxyovatodiolide (2) and anisomelic acid (3). The structures of the novel compounds were deduced by the comparison of spectral data with those of known relative compounds. Isolated compounds were subjected to the examination of inhibitory activity of angiotensin converting enzyme, cytotoxic activity and calcium antagonistic activity.

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