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DOI: 10.1055/s-2006-960915
© Georg Thieme Verlag Stuttgart · New York
Antinarcotic Effects of Standardized Ginseng Extract G115 on Morphine
Publikationsverlauf
1989
Publikationsdatum:
05. Januar 2007 (online)
Abstract
The study was undertaken to determine the antagonism of morphine analgesia by the standardized ginseng extract Gl15 from Panax ginseng, the inhibitory effects of orally administered G115 on the development of morphine-induced tolerance and physical dependence, the hepatic glutathione levels, the inhibitory effects of intraperitoneally administered G115 on the dopamine receptor supersensitivity, and the reverse tolerance to the locomotor accelerating effect of morphine.
G115 significantly inhibits the development of morphine-induced tolerance and physical dependence, the hepatic glutathione level decrease induced by morphine multiple injections, the development of morphine-induced dopamine receptor supersensitivity, and reverse tolerance to the locomotor accelerating effect of morphine. It did not, however, antagonize morphine analgesia.
Key words
Morphine - ginseng extract G 115 - tolerance - glutathione - dopamine supersensitivity - reverse tolerance