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Thromb Haemost 1966; 16(03/04): 430-442
DOI: 10.1055/s-0038-1655601
Originalarbeiten — Original Articles — Travaux Originaux
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Action of Newcastle Disease Virus on Human Blood Platelets[*]

I Cohen
1   Rogoff-Wellcome Medical Research Institute, Department of Experimental Biology and Clinical Laboratory, Tel-Aviv University Medical School, and Labor Sickfound, Beilinson Hospital, Petah Tikva, and Israel Institute for Biological Research, Ness Ziona, Israel
,
E Kaminsky
1   Rogoff-Wellcome Medical Research Institute, Department of Experimental Biology and Clinical Laboratory, Tel-Aviv University Medical School, and Labor Sickfound, Beilinson Hospital, Petah Tikva, and Israel Institute for Biological Research, Ness Ziona, Israel
,
H Joshua
1   Rogoff-Wellcome Medical Research Institute, Department of Experimental Biology and Clinical Laboratory, Tel-Aviv University Medical School, and Labor Sickfound, Beilinson Hospital, Petah Tikva, and Israel Institute for Biological Research, Ness Ziona, Israel
,
Ch Klibansky
1   Rogoff-Wellcome Medical Research Institute, Department of Experimental Biology and Clinical Laboratory, Tel-Aviv University Medical School, and Labor Sickfound, Beilinson Hospital, Petah Tikva, and Israel Institute for Biological Research, Ness Ziona, Israel
,
A Kohn
1   Rogoff-Wellcome Medical Research Institute, Department of Experimental Biology and Clinical Laboratory, Tel-Aviv University Medical School, and Labor Sickfound, Beilinson Hospital, Petah Tikva, and Israel Institute for Biological Research, Ness Ziona, Israel
,
A De Vries
1   Rogoff-Wellcome Medical Research Institute, Department of Experimental Biology and Clinical Laboratory, Tel-Aviv University Medical School, and Labor Sickfound, Beilinson Hospital, Petah Tikva, and Israel Institute for Biological Research, Ness Ziona, Israel
› Author Affiliations
Further Information

Publication History

Publication Date:
26 June 2018 (online)

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Summary

Newcastle Disease Virus induces a viscous metamorphosis like process in washed platelets.

This virus liberates from platelets lactic dehydrogenase and pyruvate kinase, depletes their ATP content and impairs their ability to concentrate 5-hydroxy-tryptamine.

Since Newcastle Disease Virus has adenosine triphosphatase activity, a possible role of this viral enzyme in the production of viscous metamorphosis and in inhibition of clot retraction is discussed.

Treatment of platelets by Newcastle Disease Virus or by particulate fraction from normal allantoic fluid causes liberation of a platelet factor 3-like substance.

* This study was supported by grant AI-04211 from the National Institute of Health, USA.


 

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