Download PDF
Thromb Haemost 1961; 6(02): 381-385
DOI: 10.1055/s-0038-1654569
Vorläufige Mitteilungen — Preliminary Reports — Communications Préliminaires
Schattauer GmbH

The Influence of Some Anticoagulants and Fibrinolytic Substances on Mice Fibroblasts (Strain L) in Tissue Culture

K Peters
1   Department of Radiology (Head: Prof. Dr. R. Bauer) and the Department of Surgery (Head: Prof. Dr. W. Dick) of the University of Tübingen
,
P Matis
1   Department of Radiology (Head: Prof. Dr. R. Bauer) and the Department of Surgery (Head: Prof. Dr. W. Dick) of the University of Tübingen
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

    Permissions and Reprints

Summary

The action of some anticoagulants and fibrinolytic substances on the culture of mice fibroblasts is described. Actase and streptokinase show a relatively high toxicity. Beta-heparins are more toxic than alpha-heparins. For pentosans the cytotoxic action is inversely proportional to the molecular weight. Marcoumar is more toxic than coumarin without anticoagulant activity. Variations of the concentration of factors VII, IX and X are of no importance for the cells. Cells 4 hours after explantation are not basically more sensitive than cells 24 hours after explantation.

 

  • References

  • (1) Fischer A. Die Bindung yon Heparin an lebende Zellen. Scand. Arch. Physiol. 75: 121 1936;
    CrossrefPubMedGoogle Scholar
  • (2) Fischer A. Über die Wirkung des Heparins auf das Wachstum von Gewebezellen m vitro. Protoplasma 26: 344 1936;
    CrossrefPubMedGoogle Scholar
  • (3) Peters K. Fortschr. Röntgenstr. 88: 50 1958;
    Article in Thieme ConnectPubMed
  • (4) Schmidt J, Stockinger L. Zellwachstum und Dicumarine. Wien. Z. inn. Med. 32: 67 1952;
    PubMedGoogle Scholar
  • (5) Zakrzewski Z. Untersuchungen über den Einfluß von Heparin auf das Wachstum von Sarkomzellen in vitro. Z. Krebsforsch. 36: 513 1932;
    CrossrefPubMedGoogle Scholar
  • (6) Zakrzewski Z. Die Rolle des Prothrombins und Heparins bei der Proliferation und Differenzierung von Geweben. Untersuchungen in vitro. Arch. exp. Zellforsch. 13: 152 1932;
    PubMedGoogle Scholar